银翘蓝芩口服液对鸡的安全性试验

发布时间：2018-03-05 04:20

本文选题：银翘蓝芩口服液　切入点：安全性　出处：《动物医学进展》2017年07期 　论文类型：期刊论文

【摘要】：依据兽药研究技术指导原则,开展银翘蓝芩口服液对靶动物鸡的安全性研究,为其临床应用的安全性提供数据资料。按银翘蓝芩口服液临床推荐剂量的1、3、5倍连续饮水给药7d,给药前后,逐只称重。试验结束后采集血液和组织器官,进行血常规、血液生化指标、脏器指数及病理组织学观察。结果表明,与对照组相比,各给药组鸡只的体重、血常规、血液生化及脏器指数等指标差异均不显著(P0.05),各组织器官未见明显的病理组织学变化。说明银翘蓝芩口服液饮水给药对靶动物鸡是安全的。
[Abstract]:According to the technical guiding principle of veterinary drug research, the safety of Yinqiao Lanqin oral liquid to the target animal chicken was studied. To provide data for the safety of clinical application. According to the recommended clinical dose of Yinqiao Lanqin oral liquid, the drug was continuously administered in drinking water for 7 days, weighing one by one before and after administration. Blood and tissue organs were collected and blood routine was performed after the trial. The blood biochemical indexes, viscera index and histopathology were observed. The results showed that compared with the control group, the body weight and blood routine of the chickens in each administration group were higher than those in the control group. There was no significant difference in blood biochemistry and visceral index, but no obvious histopathological changes in tissues and organs, which indicated that Yinqiao Lanqin oral solution was safe for target chickens.
【作者单位】：中国农业科学院兰州畜牧与兽药研究所/农业部兽用药物创制重点实验室/甘肃省新兽药工程重点实验室;
【基金】：公益性行业(农业)科研专项(201303040-12)
【分类号】：S853.7

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