Wnt信号通路在牛胎盘发育过程中的功能研究进展

发布时间：2018-03-30 00:00

本文选题：牛　切入点：胎盘　出处：《中国畜牧兽医》2017年01期

【摘要】：胎盘是哺乳动物在妊娠期间胎儿和母体之间的联系枢纽,因此,胎盘发育是否正常在妊娠中起着关键的作用。Wnt信号通路在胚胎发育和胎盘形成的过程中有着重要的作用,作者通过回顾几条已经研究较为清楚的Wnt信号通路和牛早期胚胎和胎盘的形成过程,介绍了Wnt信号通路的组成部分在体细胞核移植(somatic cell nuclear transfer,SCNT)牛和正常人工授精的牛的胚胎早期表达,提出了DKK-1和Fzd4的表达对于早期胎盘形成和发育有特殊的作用。此外,抑制MAP2K和GSK3信号可以激活Wnt信号通路,增加内细胞团和滋养层细胞的数量,加速囊胚的发育。SCNT牛和正常人工授精的牛早期胎盘中E-cadherin和β-catenin蛋白的磷酸化程度相似,所以对于Wnt信号通路在牛胎盘的早期形成和发育中的作用还需进一步的了解和研究。
[Abstract]:Placenta is the junction between fetus and mother during pregnancy. Therefore, placental development plays a key role in pregnancy. Wnt signaling pathway plays an important role in the process of embryo development and placenta formation. The authors reviewed several clear Wnt signaling pathways and the formation of bovine early embryos and placentas. This paper introduces the early expression of Wnt signaling pathway in somatic cell nuclear transfer cattle and normal artificial insemination cattle. It is suggested that the expression of DKK-1 and Fzd4 plays a special role in the formation and development of early placenta. Inhibition of MAP2K and GSK3 signals activated the Wnt signaling pathway, increased the number of inner cell mass and trophoblast cells, and accelerated the development of blastocysts. The phosphorylation of E-cadherin and 尾 -catenin proteins in bovine placenta was similar to that in normal bovine placentas. Therefore, the role of Wnt signaling pathway in the early formation and development of bovine placenta needs to be further understood and studied.
【作者单位】：黑龙江八一农垦大学动物科技学院;
【基金】：高等学校博士学科点专项科研基金(20132305120003)
【分类号】：S823

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