谷氨酰胺对脂多糖应激仔猪生长性能及血清生化指标的影响

发布时间：2018-04-20 03:27

本文选题：谷氨酰胺 + 仔猪　；参考：《动物营养学报》2017年05期

【摘要】：本试验旨在研究饲粮中添加谷氨酰胺(Gln)对断奶仔猪不同阶段生长性能的影响,以及其对脂多糖(LPS)诱导肠道损伤后断奶仔猪血清生化指标和生长性能的影响。选用24头28日龄健康的"杜×长×大"三元杂交断奶仔猪,随机分为3组,每组8个重复,每个重复1头猪。对照组和LPS组饲喂基础饲粮,Gln+LPS组饲喂添加了1%的外源性Gln的基础饲粮;在试验第22、25、28、30天,LPS组和Gln+LPS组腹腔注射100μg/kg BW LPS,对照组则注射相同剂量的生理盐水。试验期30 d。结果表明:1)LPS处理前(试验第1~21天),与对照组相比,Gln+LPS组显著提高了试验第1~7天断奶仔猪的平均日采食量(ADFI)和平均日增重(ADG)(P0.05),显著提高了试验第8~14天和第1~21天断奶仔猪的ADFI(P0.05)。2)LPS处理后(试验第22~30天),对照组断奶仔猪的ADFI、ADG、第30天体重均显著高于LPS组和Gln+LPS组(P0.05),Gln+LPS组断奶仔猪的ADFI、ADG、第30天体重均高于LPS组(P0.05)。3)LPS组断奶仔猪的小肠长度显著低于对照组和Gln+LPS组(P0.05),而对照组和Gln+LPS组之间无显著差异(P0.05)。4)与对照组相比,Gln+LPS组断奶仔猪的血清高密度脂蛋白胆固醇(HDLC)含量和碱性磷酸酶(ALP)活性显著降低(P0.05),而Gln+LPS组与LPS组之间无显著差异(P0.05);Gln+LPS组和LPS组断奶仔猪的血清免疫球蛋白M(Ig M)含量显著提高(P0.05)。由此可见,饲粮中添加1%的Gln能够显著提高仔猪断奶后第1~7天的生长性能,之后效果不明显。饲粮中添加1%的Gln能够调节应激仔猪的血清生化指标,改善其生长性能和小肠长度,从而缓解仔猪断奶应激。
[Abstract]:The purpose of this study was to study the effects of glutamine glutamine (Gln) on growth performance of weaned piglets at different stages, and on serum biochemical indexes and growth performance of weaned piglets after intestinal injury induced by lipopolysaccharide (LPS). Twenty-four 28 days old healthy "du 脳 long 脳 big" three-way crossbred weanling piglets were randomly divided into 3 groups with 8 replicates in each group and 1 pig per replica. The control group and LPS group were fed basic diet supplemented with 1% exogenous Gln, the control group and Gln LPS group were intraperitoneally injected with 100 渭 g/kg LBW, and the control group was injected with the same dose of normal saline. The trial period was 30 days. The results showed that the average daily feed intake (ADFI) and daily daily gain (ADGG) of weaned piglets were significantly higher than that of the control group on the 1st day and the 21st day of the experiment, respectively, and the weaning piglets on the 814 and 121 days of the experiment were significantly higher than those of the control group. After ADFI(P0.05).2)LPS treatment, the body weight of the weaned piglets in the control group was significantly higher than that in the LPS group and Gln LPS group on the 30th day, and the body weight on the 30th day was significantly higher than that in the LPS group and the Gln LPS group in the weaning piglets. The body weight on the 30th day was significantly higher than that in the LPS group. Compared with the control group, the serum high density lipoprotein cholesterol (HDL-C) content and alkaline phosphatase (ALP) activity of the weaned piglets in the GLN LPS group were significantly lower than those in the control group and the Gln LPS group, but Gln was significantly lower than that in the control group. There was no significant difference between the LPS group and the LPS group. The content of serum immunoglobulin (M(Ig M) in the weaned piglets in the P0.05Gln LPS group and LPS group was significantly higher than that in the P0.05 group. It can be seen that adding 1% Gln to the diet can significantly improve the growth performance of piglets on the 1st day after weaning, but the effect is not obvious. Dietary supplementation of 1% Gln could regulate serum biochemical indexes, improve growth performance and intestinal length of stressed piglets, and relieve weaning stress.
【作者单位】：中国科学院亚热带农业生态研究所亚热带农业生态过程重点实验室湖南省畜禽健康养殖工程技术中心农业部中南动物营养与饲料科学观测实验站;中国科学院大学;湖南农业大学动物科学技术学院;湘潭大学;
【基金】：国家973课题(2013CB127301) 中科院百人计划项目国家自然科学基金面上项目(31472107)
【分类号】：S828.5

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