抗脂肪细胞膜蛋白抗体对试验性肥胖大鼠5种激素水平的影响

发布时间：2018-04-27 13:19

  本文选题：抗脂肪细胞膜蛋白抗体 + 试验性肥胖大鼠　； 参考：《动物医学进展》2017年01期

【摘要】：为了验证抗脂肪细胞膜蛋白抗体减少动物脂肪沉积的作用效果,并对该抗体用于人类肥胖的治疗提供理论依据和试验资料,本试验分别对4组试验性肥胖大鼠注射0、0.1、0.5、1.0mg/mL剂量的抗脂肪细胞膜蛋白抗体,并检测4周内大鼠血清中5种激素含量及变化。结果显示,试验组血清中胰岛素(INS)含量低于对照组,Ⅰ组与Ⅳ组4周内均差异显著(P0.05);试验组与对照组、胰岛素样生长因子1(IGF-1)含量无显著差异(P0.05);注射抗体后,试验组生长激素(GH)含量显著增高,且Ⅰ、Ⅲ组4周内均差异显著(P0.05);第1周内,试验组三碘甲状腺原氨酸(T3)含量与对照组无显著差异(P0.05),后3周内Ⅰ组和Ⅳ组差异显著(P0.05);第1、3、4周内,Ⅰ组和Ⅳ组四碘甲状腺原氨酸(T4)含量差异显著(P0.05),第2周内无显著差异,Ⅱ组和Ⅲ组差异均不显著(P0.05)。此外,不同组间的差异显著性随注射剂量不同而不同。
[Abstract]:In order to verify the effect of anti-adipose cell membrane protein antibody on reducing fat deposition in animals, and to provide theoretical basis and experimental data for the treatment of human obesity. Four groups of experimental obese rats were injected with 0.5 mg / mL anti-adipose cell membrane protein antibody at a dose of 0.5 mg / mL, and the levels and changes of 5 hormones in serum were measured within 4 weeks. The results showed that the content of insulin in the serum of the experimental group was lower than that of the control group, and the difference between group 鈪，

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