γ-氨基丁酸与延胡索乙素配伍对小鼠急性疼痛模型的镇痛作用

发布时间：2018-05-02 14:52

  本文选题：延胡索乙素(L-THP) + γ-氨基丁酸(GABA)　； 参考：《黑龙江畜牧兽医》2017年14期

【摘要】：为了了解中药延胡索乙素(L-THP)与γ-氨基丁酸(GABA)配伍对动物模型的镇痛作用,试验以小鼠急性疼痛为模型,以布洛芬、吗啡为参照药物,通过小鼠醋酸扭体试验和小鼠甲醛致痛试验,分别观察记录用药小鼠在注射致痛剂后20 min内的扭体次数和舔注射足时间。结果表明:LTHP与GABA配伍,在25~200 mg/kg浓度时具有良好的外周镇痛作用,能明显抑制醋酸致小鼠扭体反应。甲醛致小鼠的Ⅱ相疼痛反应,L-THP与GABA配伍的作用强于或等于布洛芬;而对甲醛致小鼠的Ⅰ相疼痛反应,L-THP与GABA配伍的作用与布洛芬相似,弱于吗啡,说明L-THP与GABA配伍可用于疼痛应急疾患。
[Abstract]:In order to understand the analgesic effect of the combination of tetrahydropalmatine L-THPand 纬 -aminobutyric acid (GABA) on animal model, acute pain model in mice and ibuprofen and morphine as reference drugs were used in the experiment. By acetic acid writhing test and formaldehyde-induced pain test, the writhing times and the time of licking injection were recorded within 20 min after injection. The results showed that the compatibility of GABA with GABA had a good peripheral analgesic effect at the concentration of 25 mg/kg and could inhibit the writhing reaction induced by acetic acid in mice. The phase 鈪，

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