分支杆菌Rv0024诱导生物膜的形成和抗细胞壁作用研究进展

发布时间：2018-05-17 00:37

本文选题：分支杆菌 + Rv　；参考：《动物医学进展》2017年07期

【摘要】：多药耐药结核菌和广泛耐药结核菌的出现,使得结核病成为全球第二大传染病。而生物膜的形成在几个人类病原体发病机制作用是公认的。然而,在结核分支杆菌感染情况下生物膜的作用和生物膜形成的遗传因素仍然存在很大程度上的未知。论文通过查阅大量外文文献阐述了细胞壁在结核分支杆菌中的耐药机制,并且发现生物膜中Rv0024为新的NlpC/p60蛋白质家族的一员,通过结核分支杆菌Rv0024异位表达,编码一个假定的肽酶,并且随着抗结核药物异烟肼和吡嗪酰胺耐药性的出现,生物膜形成的Rv0024也显著增加。Rv0024可能在初次感染过程中发挥了关键作用,参与宿主细胞的耐药性产生。因此,Rv0024可作为治疗肺结核的一个潜在的药物靶标进行深入研究。
[Abstract]:The emergence of multi-drug-resistant tuberculous bacilli and widespread drug-resistant tuberculous bacilli makes tuberculosis the second-largest infectious disease in the world. The formation of biofilm in several human pathogens pathogenesis is recognized. However, the role of biofilm and genetic factors of biofilm formation remain largely unknown in the case of Mycobacterium tuberculosis infection. In this paper, the mechanism of cell wall resistance in Mycobacterium tuberculosis was explained by consulting a large number of foreign literatures, and it was found that Rv0024 in biofilm was a member of a new NlpC/p60 protein family and expressed ectopic through Rv0024 of Mycobacterium tuberculosis. Encoding a hypothetical peptidase, and with the emergence of anti-tuberculosis drugs isoniazid and pyrazinamide resistance, biofilm-forming Rv0024 may also play a key role in the initial infection. Participate in the production of drug resistance in host cells. Therefore, Rv0024 can be used as a potential drug target for the treatment of pulmonary tuberculosis.
【作者单位】：吉林农业大学动物科技学院;吉林农业大学中药材学院;吉林省梅花鹿生产与产品应用研究室;
【基金】：国家自然科学基金项目(31372436) 吉林省科技厅重点科技攻关项目(20150204028NY);吉林省科技厅科技支撑计划项目(20160209006YY);吉林省科技厅产业技术创新战略联盟项目(20140309018YY)
【分类号】：S852.618

【相似文献】