硫酸头孢喹肟脂质体的毒理学试验及安全性评价

发布时间：2018-05-22 08:32

本文选题：硫酸头孢喹肟 + 脂质体　；参考：《中国畜牧兽医》2017年08期

【摘要】：采用急性毒性试验、局部刺激性试验和亚慢性毒性试验对硫酸头孢喹肟脂质体安全性进行评价,以期为临床用药提供参考。小鼠腹腔注射硫酸头孢喹肟脂质体半数致死量(LD50)为639.73mg/kg,95%可信限为573.06~714.17mg/kg;该制剂对家兔股四头肌未见明显刺激作用;各给药剂量组家兔的体重、血液学指标、生化指标与对照组比较均无显著差异(P0.05);对肝脏和肾脏病理学观察表明,正常治疗剂量和中剂量组肝脏和肾脏组织结构清晰,但高剂量组出现肝细胞排列紊乱,肝血窦间出血,肾小球、肾间质有散在出血。以上结果表明硫酸头孢喹肟脂质体安全可靠,可应用于兽医临床。
[Abstract]:Acute toxicity test, local irritation test and subchronic toxicity test were used to evaluate the safety of cefequinoxime sulfate liposome. The LD50 of cefquinoxime sulfate liposome injected intraperitoneally in mice was 639.73 mg 路kg ~ (-1) 路kg ~ (95)% confidence limit was 573.06 ~ 714.17 mg 路kg ~ (-1) 路kg ~ (-1). There was no obvious stimulation effect on quadriceps femoris muscle in rabbits. The pathological observation of liver and kidney showed that the structure of liver and kidney was clear in normal and middle dose groups, but the liver cells in high dose group were disordered, and the hepatic sinusoidal hemorrhage was found in high dose group. Glomeruli, renal interstitial haemorrhage scattered. These results suggest that cefequinoxime sulfate liposomes are safe and reliable and can be used in veterinary clinic.
【作者单位】：信阳农林学院;瑞普(天津)生物科技股份有限公司;信阳师范学院;
【基金】：河南省高等学校重点科研项目计划(15A230029) 信阳市科技发展计划项目(150017)
【分类号】：S859.7

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