CD4基因的DNA甲基化修饰在家畜抗病育种中的应用

发布时间：2018-05-31 13:35

本文选题：家畜 + CD基因　；参考：《畜牧兽医学报》2017年10期

【摘要】：CD4分子表达于成熟的CD4~+T细胞表面,能够指导T细胞的正常分化与成熟,识别抗原、介导免疫应答并参与免疫调节。DNA甲基化对T细胞亚群的分化调控等方面具有重要作用,特别是CD4基因的DNA甲基化显著影响CD4+T细胞数量和功能,能够在一定程度上改变家畜的免疫应答能力或抗病性能,以对抗或适应外界环境改变。目前,已发现猪和奶牛的CD4基因DNA甲基化可调控宿主细胞的免疫反应,但在羊和马上鲜有报道。为深入了解家畜复杂疾病形成的分子基础,以及为利用分子标记有效选育抗病个体提供新的思路,本文主要就CD4+T淋巴细胞分化过程中,白细胞分化抗原CD4基因的DNA甲基化修饰对免疫反应的调控机制,以及其在家畜抗病育种中的应用前景进行综述和展望。
[Abstract]:CD4 molecules are expressed on the surface of mature CD4~+T cells, which can guide the normal differentiation and maturation of T cells, identify the antigen, mediate the immune response and participate in the immunoregulation of.DNA methylation on the differentiation and regulation of the T cell subsets. Especially, the DNA methylation of the CD4 gene significantly affects the number and function of CD4+T cells, and can be used in one of the CD4+T cells. At present, the CD4 gene DNA methylation of pigs and cows has been found to regulate the immune response of host cells, but it is rarely reported in sheep and at once. It is a molecular basis for understanding the formation of complex diseases in domestic animals and for the use of molecular markers. In this paper, a new idea is provided for the effective breeding of disease resistant individuals. This article is mainly about the regulatory mechanism of the DNA methylation modification of the leukocyte differentiation antigen (CD4) gene in the process of CD4+T lymphocyte differentiation, and the prospect of its application in livestock breeding.
【作者单位】：内蒙古农业大学职业技术学院;中国农业大学动物科技学院;
【基金】：内蒙古自然科学基金(2016BS0305) 国家自然科学基金(31272420;31572361) 北京市奶牛产业创新团队项目(BAIC06-2017)
【分类号】：S813

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