烯丙孕素口服液对靶动物猪的安全性研究

发布时间：2018-06-06 01:39

本文选题：猪 + 烯丙孕素　；参考：《中国兽药杂志》2017年10期

【摘要】：为评价烯丙孕素口服液对猪的安全性,将24头达到性成熟的苏姜母猪随机分为4组,每组6头,采用多剂量水平给药进行靶动物安全性研究,其中受试药物设最大推荐剂量每头动物每日20 mg烯丙孕素(相当于每次5 m L)、2倍最大推荐剂量每头动物每日40 mg烯丙孕素(相当于每次10 m L)和3倍最大推荐剂量每头动物每日60 mg烯丙孕素(相当于每次15 m L)三个剂量组;另设一空白对照组,每头动物每日15 m L洁净自来水,体积相当于3倍受试药推荐剂量的体积。通过一般临床观察、各组动物体重、血液学和血液生化学参数等指标及组织病理学检测或观察,评价烯丙孕素在临床用药的安全性。结果表明,试验期间各组猪均未死亡且健康良好,期间临床表现正常,3倍最大推荐剂量组剖检动物各组织器官未发现病理变化。在血液生理指标及生化指标方面,推荐剂量组、2倍推荐剂量组、3倍最大推荐剂量组与空白对照组相比,除少部分指标外,其他各指标并无显著差异。试验结果说明,烯丙孕素在推荐剂量下使用在靶动物猪上具有较高的安全性。
[Abstract]:In order to evaluate the safety of allylpregnancy oral liquid in pigs, 24 sujiang sows with sexual maturity were randomly divided into 4 groups, 6 in each group, and the safety of target animals was studied by multi-dose administration. Of these drugs, the maximum recommended dose per animal was 20 mg / day (equivalent to 2 times the maximum recommended dose of 5 m L / d) and the maximum recommended dose of 40 mg / day (10 mL / day) and 3 times the maximum recommended dose per animal. Each animal was given 60 mg of allopretin per day (equivalent to 15 mL each time) in three dose groups; A blank control group was set up with 15 mL clean tap water per day for each animal. The volume was equivalent to the volume of 3 recommended doses for each animal. The safety of allylpregnancy was evaluated by general clinical observation, body weight, hematological and biochemical parameters and histopathological examination. The results showed that the pigs in each group were not dead and healthy during the trial period, and no pathological changes were found in all tissues and organs of the animals in the group with 3 times normal clinical manifestations and the maximum recommended dose. In terms of blood physiological and biochemical indexes, there was no significant difference between the recommended dose group and the blank control group, except for a few indexes, the maximum recommended dose group was 3 times and the maximum recommended dose group was 3 times as compared with the blank control group. The results show that allylpregnancy has high safety in target pigs at recommended dose.
【作者单位】：扬州大学兽医学院;江苏省动物重要疫病与人兽共患病防控协同创新中心;宁波第二激素厂;
【基金】：基金项目:江苏高校优势学科建设工程(PAPD)
【分类号】：S859.7

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