不同伪狂犬病活疫苗免疫效力比较

发布时间：2018-06-08 23:20

本文选题：伪狂犬病 + 活疫苗　；参考：《中国兽药杂志》2017年01期

【摘要】：为临床科学选用疫苗,对来自三个生物制品厂的伪狂犬病活疫苗的免疫效力进行了评价。试验选取35日龄伪狂犬阴性猪20头,试验根据疫苗接种情况分为5组,分别为:免疫疫苗稀释液的对照组(第一组)、免疫进口活疫苗组(第二组)、免疫国产活疫苗组(第三组)、免疫本公司ST细胞系增殖制备活疫苗组(第四组)、免疫本公司鸡胚成纤维细胞增殖制备活疫苗组(第五组),然后进行免疫监测和效力评价,观察不同疫苗组仔猪的抗体水平后攻毒保护情况。结果显示:一次免疫后各组抗伪狂犬病毒抗体水平增长缓慢,进行二次免疫后,抗体水平迅速增加并保持较高水平。攻毒后,从身体耐受性、体温变化、体重下降率以及g E抗体水平来看,第二组疫苗B和第四组疫苗D耐受性较强,较快恢复健康,体重下降率较小且g E抗体水平较高。
[Abstract]:The Immunization Effectiveness of the pseudorabies live vaccine from three biological products factories was evaluated for the clinical science. The test selected 20 35 day old pseudorabies negative pigs, and the test was divided into 5 groups according to the vaccine inoculation, respectively: the control group (the first group), the immune imported live vaccine group (second groups), the immune countries. Live vaccine group (third groups), immunization of the ST cell line of the company to prepare live vaccine group (fourth groups), immunization of chicken embryo fibroblast cell proliferation to prepare live vaccine group (fifth groups), and then carry out immune monitoring and efficacy evaluation, observe the protection of anti body level after the anti body level of piglets in different vaccine groups. The results show: one immunization group after one immunization. The level of anti pseudorabies virus increased slowly. After two times of immunization, the level of antibody increased rapidly and maintained a high level. After the attack, the second groups of vaccines B and fourth groups of vaccines, B and fourth groups, were well tolerated and recovered quickly from body tolerance, body temperature, body weight loss and the level of E antibody. The rate of weight loss was relatively small and G E antibody was low. The level is high.
【作者单位】：湖南中岸生物药业有限公司;
【分类号】：S855.3

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