网状内皮组织增殖病病毒免疫抑制状态下禽波氏菌对雏鸡致病性增强

发布时间：2018-06-10 19:10

本文选题：禽波氏菌 + 网状内皮增殖病病毒　；参考：《畜牧兽医学报》2017年08期

【摘要】：禽波氏菌可引起禽类的高度接触性上呼吸道疾病,且经常与免疫抑制性病毒发生共感染。为研究免疫抑制状态下禽波氏菌致病性的变化,试验中以网状内皮组织增殖病病毒(REV)感染鸡胚构建雏鸡的免疫抑制状态,雏鸡孵出后再经呼吸道感染禽波氏菌,模拟临床二者的混合感染。分别监测混合感染与单纯感染条件下雏鸡的生长状况、免疫器官指数、NDV灭活苗免疫抗体水平、禽波氏菌抗体水平、禽波氏菌入侵组织时间、组织病理学变化以及其他细菌的继发感染状况等。结果发现REV感染可导致雏鸡严重的生长抑制和免疫抑制作用,感染禽波氏菌后使抑制作用加重,且干扰了针对禽波氏菌的抗体的产生。禽波氏菌在REV免疫抑制状态雏鸡肝、心和肾中的检出时间比单纯感染组提前了1d。混合感染组雏鸡气管黏膜完全脱落,肝、心等组织内细胞广泛性坏死,细菌继发感染病例数增多。REV免疫抑制状态下,机体防御体系被破坏,对禽波氏菌的免疫应答降低,为禽波氏菌在组织中的侵袭扩散提供了便利,使禽波氏菌对雏鸡的致病性增强。
[Abstract]:Botrytis fowls can cause high contact upper respiratory diseases in birds and often co-infect with immunosuppressive viruses. In order to study the pathogenicity of Bordetella fowl under immunosuppressive state, the chicken embryo was infected with reticuloendotheliosis virus (Rev). To simulate the clinical mixed infection of both. The growth status, immune organ index, immune antibody level of NDV inactivated vaccine and invasion time of Botrytis fowl were monitored under mixed infection and simple infection respectively. Histopathological changes and secondary infections of other bacteria. The results showed that Rev infection could lead to serious growth inhibition and immunosuppressive effect in chicks. The detection time of Bordetella fowls in the liver, heart and kidney of rev immunosuppressive chicks was 1 day earlier than that in the simple infection group. In the mixed infection group, the tracheal mucosa was completely shedded, the cells in the tissues of liver and heart were widely necrosed, the number of secondary bacterial infection cases increased, and the body defense system was destroyed and the immune response to Botrytis fowls was decreased under the immunosuppressive state of Rev. It provided convenience for the invasion and diffusion of Bordetella fowls in tissues and enhanced its pathogenicity to chicks.
【作者单位】：山东农业大学动物科技学院;山东省动物疫病预防与控制中心;
【基金】：国家自然科学基金(31602067;31272595) 山东省自然科学基金(ZR2014CM044) 山东农业大学青年科技创新基金(23821) 山东省一流学科建设资金(FSDTP)
【分类号】：S858.31

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