大环内酯类抗寄生虫药在骆驼体内的药动学研究进展
发布时间：2018-07-13 20:08
【摘要】：为有效防治骆驼寄生虫病和临床合理用药提供科学依据,在大量查阅大环内酯类抗寄生虫药物伊维菌素(IVM)、依普菌素(EPR)及莫西菌素(MXD)在骆驼体内和牛、羊体内的药动学研究文献资料的基础上,进行了较为全面地比较分析。主要从大环内酯类抗寄生虫药物IVM、MXD及EPR的理化特性、作用机理以及它们在骆驼、牛和羊体内的药代动力学特征等方面加以综述,并为骆驼临床合理用药、提高药物疗效以及骆驼专用新剂型的研发等方面提出了见解。
[Abstract]:In order to provide scientific basis for effective prevention and treatment of camel parasitosis and rational use of drugs in clinic, Ivermectin (IVM), EPR and MXD (macrolide antiparasitic drugs) were found in camels and cattle. Based on the literature of pharmacokinetics in sheep, a comparative analysis was carried out. In this paper, the physicochemical properties, action mechanism and pharmacokinetic characteristics of macrolides antiparasitic drugs IVMMXD and EPR in camels, cattle and sheep were reviewed. To improve the efficacy of the medicine and the development of a new dosage form for camel, some suggestions were put forward.
【作者单位】： 内蒙古农业大学兽医学院农业部动物疾病临床诊疗技术重点实验室;
【基金】：国家自然科学基金项目(31260623)
【分类号】：S859.795
本文编号：2120594
[Abstract]:In order to provide scientific basis for effective prevention and treatment of camel parasitosis and rational use of drugs in clinic, Ivermectin (IVM), EPR and MXD (macrolide antiparasitic drugs) were found in camels and cattle. Based on the literature of pharmacokinetics in sheep, a comparative analysis was carried out. In this paper, the physicochemical properties, action mechanism and pharmacokinetic characteristics of macrolides antiparasitic drugs IVMMXD and EPR in camels, cattle and sheep were reviewed. To improve the efficacy of the medicine and the development of a new dosage form for camel, some suggestions were put forward.
【作者单位】： 内蒙古农业大学兽医学院农业部动物疾病临床诊疗技术重点实验室;
【基金】：国家自然科学基金项目(31260623)
【分类号】：S859.795
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