动物宿主microRNAs抗病毒作用机制研究进展
发布时间：2018-07-26 19:49
【摘要】：microRNAs(miRNAs)是一种长度为22nt的非编码RNA分子,能够结合mRNA,影响翻译效率,调控蛋白的表达。近来多项研究表明,动物宿主miRNAs通过多种机制抑制病毒的复制,如直接靶向病毒基因、干扰病毒复制所需因子、调节先天性免疫、调节细胞凋亡、调节细胞免疫,发挥抗病毒效应。本文归纳总结宿主miRNAs对病毒复制的调控机制,讨论miRNAs类抗病毒药物的应用情况,并展望该类药物的发展趋势。
[Abstract]:MicroRNAs (miRNAs) is a non-coding RNA molecule with length of 22nt, which can bind to mRNAs, affect translation efficiency and regulate the expression of proteins. A number of recent studies have shown that animal host miRNAs inhibits viral replication through a variety of mechanisms, such as direct targeting of virus genes, interfering with the factors required for viral replication, regulating innate immunity, regulating cell apoptosis, and regulating cellular immunity. Give play to the antiviral effect. In this paper, the mechanism of host miRNAs regulating virus replication is summarized, the application of miRNAs antiviral drugs is discussed, and the development trend of this kind of drugs is prospected.
【作者单位】： 中国动物卫生与流行病学中心外来病研究中心;青岛市动物疫病预防控制中心;
【基金】：“十三五”国家重点研发计划(项目号:2016YFD0500108),题目:小反刍兽疫病毒感染与免疫调控机制研究~~
【分类号】：S852.65
，
本文编号：2147107
[Abstract]:MicroRNAs (miRNAs) is a non-coding RNA molecule with length of 22nt, which can bind to mRNAs, affect translation efficiency and regulate the expression of proteins. A number of recent studies have shown that animal host miRNAs inhibits viral replication through a variety of mechanisms, such as direct targeting of virus genes, interfering with the factors required for viral replication, regulating innate immunity, regulating cell apoptosis, and regulating cellular immunity. Give play to the antiviral effect. In this paper, the mechanism of host miRNAs regulating virus replication is summarized, the application of miRNAs antiviral drugs is discussed, and the development trend of this kind of drugs is prospected.
【作者单位】： 中国动物卫生与流行病学中心外来病研究中心;青岛市动物疫病预防控制中心;
【基金】：“十三五”国家重点研发计划(项目号:2016YFD0500108),题目:小反刍兽疫病毒感染与免疫调控机制研究~~
【分类号】：S852.65
，
本文编号：2147107
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