肠黏膜上皮组织紧密连接的生物学功能和作用机理
发布时间：2018-08-09 18:33
【摘要】：紧密连接(TJ)是肠黏膜上皮细胞间的主要连接方式,对维持黏膜上皮细胞极性及调节肠屏障的通透性发挥着重要的作用。TJ在黏膜上皮细胞间形成限制溶质和物质运动的细胞屏障。总的来说,TJ的结构可以概括为跨膜屏障蛋白与周围的脚手架蛋白组成的间隔。在这个复杂的网络中有许多相关的信号蛋白,影响屏障和更广泛的细胞功能。本文从TJ在肠黏膜上皮中的生物学功能、分子调控机制及当前研究现状等作综合阐述。
[Abstract]:Tight junction of (TJ) is the main connection between intestinal epithelial cells, which plays an important role in maintaining the polarity of mucosal epithelial cells and regulating the permeability of intestinal barrier. TJ forms a cell barrier between mucosal epithelial cells that restricts solute and substance movement. In general, the structure of TJ can be summarized as the interval between the transmembrane barrier protein and the surrounding scaffold protein. In this complex network there are many associated signaling proteins that affect the barrier and wider cellular functions. In this paper, the biological function of TJ in intestinal mucosal epithelium, the mechanism of molecular regulation and the current research status are reviewed.
【作者单位】： 沈阳农业大学畜牧兽医学院;乐达(广州)香味剂有限公司;
【分类号】：S852.2
本文编号：2174940
[Abstract]:Tight junction of (TJ) is the main connection between intestinal epithelial cells, which plays an important role in maintaining the polarity of mucosal epithelial cells and regulating the permeability of intestinal barrier. TJ forms a cell barrier between mucosal epithelial cells that restricts solute and substance movement. In general, the structure of TJ can be summarized as the interval between the transmembrane barrier protein and the surrounding scaffold protein. In this complex network there are many associated signaling proteins that affect the barrier and wider cellular functions. In this paper, the biological function of TJ in intestinal mucosal epithelium, the mechanism of molecular regulation and the current research status are reviewed.
【作者单位】： 沈阳农业大学畜牧兽医学院;乐达(广州)香味剂有限公司;
【分类号】：S852.2
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