吡喹酮注射液在健康水牛体内的药物动力学

发布时间：2018-08-18 21:08

【摘要】：目的研究吡喹酮注射液在水牛体内的药物动力学特征及其与吡喹酮片之间的相对生物利用度。方法选用6头健康成年水牛,采用两周期随机交叉实验设计,单剂量内服吡喹酮片(20 mg/kg)或肌注吡喹酮注射液(10 mg/kg),高效液相色谱法(HPLC)测定水牛血浆中吡喹酮浓度,进行非房室模型分析,计算药动学参数。结果水牛内服吡喹酮片的峰时(T_(max))为(0.60±0.29)h,峰浓度(C_(max))为(0.57±0.37)μg/ml,消除半衰期(T_(1/2β))为(0.70±0.42)h,药-时曲线下面积(AUC)为(0.80±0.70)(μg/ml)·h。水牛肌注吡喹酮注射液的T_(max)为(0.65±0.49)h,C_(max)为(3.82±1.17)μg/ml,T_(1/2β)为(1.00±0.73)h,AUC为(1.61±0.89)(μg/ml)·h。吡喹酮注射液相对于吡喹酮片的生物利用度为402.5%。结论吡喹酮注射液肌注给药后在水牛体内具有吸收迅速,生物利用度高,体内分布广的药物动力学特征,临床推荐给药剂量为10 mg/kg。
[Abstract]:Objective to study the pharmacokinetic characteristics of praziquantel injection in buffalo and its relative bioavailability with praziquantel tablets. Methods six healthy adult buffaloes were used in a two-cycle randomized crossover design. Praziquantel tablets (20 mg/kg) or praziquantel injection (10 mg/kg) were administered intramuscularly. The concentration of praziquantel in buffalo plasma was determined by high performance liquid chromatography (HPLC). The non-atrioventricular model was analyzed and pharmacokinetic parameters were calculated. Results the peak time (T _ (max) of praziquantel tablet was (0.60 卤0.29) h, the peak concentration (C _ (max) was (0.57 卤0.37) 渭 g / ml, the elimination half life (T _ (1 / 2 尾) was (0.70 卤0.42) h, and the area under the drug-time curve was (0.80 卤0.70) (渭 g/ml) h. The T _ (max) of praziquantel injection was (0.65 卤0.49) (max) (3.82 卤1.17) 渭 g 路ml ~ (-1) T _ (1 / 2 尾) was (1.00 卤0.73) HPA = (1.61 卤0.89) (渭 g/ml) h. The bioavailability of praziquantel injection was 402.5. Conclusion praziquantel injection has the characteristics of rapid absorption, high bioavailability and wide distribution in the body of buffalo after intramuscular injection. The recommended dosage of praziquantel injection is 10 mg / kg.
【作者单位】：江苏农牧科技职业学院;江苏倍康药业有限公司;扬州大学兽医学院;中国农业科学院上海兽医研究所;
【基金】：国家公益性行业(农业)科研专项(200903036) 江苏省高校青蓝工程资助项目国家农业科技成果转化资金项目(2011GB2C100019) 泰州市科技计划项目(TG1126)
【分类号】：S859.7

【相似文献】