多不饱和脂肪酸代谢及其对炎症的调节
发布时间：2018-10-10 10:03
【摘要】：炎症是一种机体对感染或组织损伤的保护性反应。适度的或可控的炎症对于入侵病原微生物的清除以及受损组织的修复是必需的,然而过度的或不可控的炎症往往会导致病理性炎症反应发生,大大提高了各种感染性和代谢性疾病的发病风险。多不饱脂肪酸代谢生成的脂质调控介质对炎症的启动、发展以及消退均具有重要的调节作用,了解多不和脂肪酸的代谢及其代谢产物对炎症反应的调节机制,对于通过饲粮营养途径控制疾病发生以及改善人和动物健康具有重要的理论和现实意义。鉴此,本文综述了多不饱和脂肪酸的代谢途径,并就其代谢产物对炎症反应的调节进行了详细论述。
[Abstract]:Inflammation is a protective response of the body to infection or tissue damage. Moderate or controllable inflammation is necessary for the clearance of invading pathogenic microorganisms and the repair of damaged tissue. However, excessive or uncontrollable inflammation often leads to pathological inflammation. It greatly increases the risk of various infectious and metabolic diseases. Lipid regulatory mediators produced by the metabolism of polyunsaturated fatty acids play an important role in the initiation, development and regression of inflammation. It has important theoretical and practical significance for controlling disease and improving human and animal health through dietary nutrition. In this paper, the metabolic pathways of polyunsaturated fatty acids are reviewed, and the regulation of their metabolites on inflammation is discussed in detail.
【作者单位】： 内蒙古师范大学生命科学与技术学院;
【基金】：国家自然科学基金项目(31560644) 内蒙古自然科学基金项目(2015MS0367) 引进高层次人才科研启动经费项目(2015YJRC005)
【分类号】：S816
，
本文编号：2261363
[Abstract]:Inflammation is a protective response of the body to infection or tissue damage. Moderate or controllable inflammation is necessary for the clearance of invading pathogenic microorganisms and the repair of damaged tissue. However, excessive or uncontrollable inflammation often leads to pathological inflammation. It greatly increases the risk of various infectious and metabolic diseases. Lipid regulatory mediators produced by the metabolism of polyunsaturated fatty acids play an important role in the initiation, development and regression of inflammation. It has important theoretical and practical significance for controlling disease and improving human and animal health through dietary nutrition. In this paper, the metabolic pathways of polyunsaturated fatty acids are reviewed, and the regulation of their metabolites on inflammation is discussed in detail.
【作者单位】： 内蒙古师范大学生命科学与技术学院;
【基金】：国家自然科学基金项目(31560644) 内蒙古自然科学基金项目(2015MS0367) 引进高层次人才科研启动经费项目(2015YJRC005)
【分类号】：S816
，
本文编号：2261363
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