影响二花脸猪高产仔性能的生理及遗传机制研究进展

发布时间：2018-11-07 07:10

【摘要】：二花脸猪是我国太湖流域以产仔数高而闻名于世界的优质猪种。已有的研究发现,二花脸猪排卵数高、胚胎死亡率低和子宫容积大是其高产性能的重要生理特征,通过候选基因法鉴别到其高产的重要候选基因——促卵泡素β亚基(follicular-stimulating hormone beta,FSH?),采用QTL定位方法在猪第2、6、7、8、12、13和15号染色体上定位到影响其产仔性状的QTL。但是,目前影响二花脸猪产仔数的主效基因尚不清楚。本文主要介绍了二花脸猪的高排卵数、低胚胎死亡率和高子宫容积特性对高产仔性能形成的生理作用;概括了基于传统方法鉴别出的影响二花脸猪高产仔性能的候选基因和QTL,以及基于组学方法鉴别出的二花脸猪高产候选基因;探讨了如何利用基因组、转录组、蛋白质组和功能组等多组学手段深入研究二花脸猪高产性能的成因,以期为深入解析二花脸猪高产性能的分子遗传机制提供参考。
[Abstract]:Erhualian Pig is one of the best breeds in the world for its high litter size in Taihu Lake Basin. Previous studies have found that high ovulation, low embryo mortality and large uterine volume are important physiological characteristics of high yield in Erhualian pigs. Follicle stimulating hormone 尾 subunit (follicular-stimulating hormone beta,FSH?), an important candidate gene with high yield, was identified by candidate gene method. QTL mapping method was used to localize QTL. on chromosomes 2, 6, 7, 8, 12, 12, 13, and 15, which affect litter production. However, the major genes that affect the litter size of Erhualian pigs are unclear. In this paper, the physiological effects of high ovulation, low embryo mortality and high uterine volume on the formation of high litter performance in Erhualian pigs were introduced. The candidate genes and QTL, which affect the high litter performance of Erhualian pigs were identified based on traditional methods and the candidate genes for high yield of Erhualian pigs were identified based on the cluster method. This paper discussed how to study the causes of high yield of Erhualian pigs by using genome, transcriptome, proteome and functional group, so as to provide reference for further analysis of molecular genetic mechanism of high yield of Erhualian pigs.
【作者单位】：南京农业大学养猪研究所;
【基金】：国家自然科学基金项目(编号:31601923) 江苏省自然科学基金项目(编号:BK20140688) 江苏省科技支撑计划项目(编号:BE2014396)资助~~
【分类号】：S828

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