抗新生仔猪腹泻制剂的研制及临床疗效的研究

发布时间：2018-11-20 04:07

【摘要】：新生仔猪腹泻病已经成为影响当今养猪产业发展的主要疾病之一,其特点是新生仔猪发病快,死亡率高,已经严重的危害着养猪产业的经济效益。本研究拟优化复方小檗碱膏剂的组方及制备工艺,初步建立其质量标准,并进行安全性评价及临床疗效的研究,结果表明:(1)复方小檗碱膏剂主要成分为盐酸小檗碱、穿心莲内酯及纳米蒙脱石,穿心莲内酯在与无水乙醇比值为1:5,甘油含量5m L,温度为65℃的情况下,穿心莲内酯的溶解性好,粘稠度高;急性毒性实验结果显示其不具有毒性作用;微生物限度、粒子大小、最低装量及稳定性均符合国家相关规定。(2)复方小檗碱膏剂对妊娠母猪及新生仔猪的血液生化指标无显著影响,各项数值均在正常范围之内,表明其对妊娠母猪及新生仔猪的肝脏功能、肾脏功能及生理功能无影响。(3)复方小檗碱膏剂可以使产后母猪恢复食欲,预防乳房炎,促进乳汁的分泌;复方小檗碱膏剂对妊娠母猪的后代具有促进生长的作用,精神状态良好,被毛光亮,食欲正常;复方小檗碱膏剂对新生仔猪具有促生长的作用,增强了新生仔猪的抗腹泻能力。(4)复方小檗碱膏剂对新生仔猪腹泻病具有治疗作用,与西药治疗腹泻药物相比,其能够快速补能,提高仔猪精神状态,加快食欲恢复,防止仔猪脱水死亡,降低死亡率。综上所述,复方小檗碱膏剂制备工艺稳定,质量标准合格,安全可靠,其临床疗效作用明显,具有可靠的临床应用前景。
[Abstract]:Diarrhea disease of newborn piglets has become one of the main diseases affecting the development of pig raising industry. Its characteristics are that newborn piglets have a fast onset and a high mortality rate, which has seriously jeopardized the economic benefits of the pig industry. This study aims to optimize the formulation and preparation process of compound berberine paste, establish its quality standard, evaluate its safety and clinical efficacy. The results show that: (1) berberine hydrochloride is the main component of compound berberine paste. When the ratio of andrographolide to anhydrous ethanol is 1: 5, glycerol content is 5m L, temperature is 65 鈩，

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