犬子宫蓄脓的临床诊断及治疗
发布时间：2019-01-01 10:03
【摘要】：犬子宫蓄脓是宠物临床常见产科疾病之一。本文从22例罹患子宫蓄脓病犬的营养状况、流行病学、血液学、影像学、组织病理、宫内微生物培养、药敏试验及治疗等方面开展研究,旨在为子宫蓄脓临床综合诊疗提供借鉴和依据。试验显示6岁以上无生育史的母犬是子宫蓄脓症的易发群体。品种、免疫状况及营养状况从数据上显示与该病无相关性。患犬临床常表现为精神沉郁,烦渴多尿、呕吐腹泻、腹围膨大、阴门红肿、阴道有异臭味分泌物排出、体温升高或下降、可视粘膜苍白等症状。血液学检测结果显示:患犬一般出现白细胞增多症,最高可达正常值3倍以上;中性粒细胞增多,幼稚型白细胞增加,可达80%以上;病程较长的患犬发生贫血;发展为败血症患犬则白细胞减少;亦有少数患犬血象正常。多数患犬会出现不同程度的肾脏和肝脏功能异常,常见血液尿素氮(BUN)增加,达12mmol/l以上;乳酸脱氢酶(LDH)大于328iu/l;谷草转氨酶(AST)大于41iu/l;总胆红素6倍与正常值;提示患犬一定程度的肝肾功能障碍。B超检查通常可观察到蓄脓子宫的形态、大小和位置;病理性子宫蓄脓B超影像多为长条状无回声均匀暗液区。患犬病变区组织病理切片显示,大多数病变部位无肿瘤生长的迹象。卵巢多见持久黄体或多囊卵泡,部分患犬可见卵巢部有粒层细胞瘤或乳头状腺瘤。闭锁型患犬常见子宫壁变薄、子宫内膜萎缩或溃疡;开放型患犬多表现为囊性子宫内膜增生及子宫内膜炎;提示闭锁型较开放型子宫蓄脓严重。从22例患犬中,全部分离到细菌,不排除有些为子宫内常态菌。主要分离到的致病菌为大肠杆菌(77.27%)和β-溶血链球菌(13.64%),其余的是葡萄球菌及芽孢菌。说明大肠杆菌是引起子宫蓄脓的主要致病菌,其对卡那霉素和新霉素的敏感率最高,均达到了100%。根据临床症状、血液学检查、影像学检查及细菌分离药敏试验的结果对患犬采用不同的治疗方法,22例患犬全部治愈。其中对6例患犬采取保守疗法,占治愈总数的27.27%;有16例采取手术疗法,占治愈总数的72.73%。迄今为止,卵巢子宫全摘除术仍是治疗子宫蓄脓的首选方法。对于有重要育种价值或其他原因无法进行手术的患犬,可考虑施行子宫冲洗,并结合宫内细菌药敏试验采取针对性强的抗菌消炎等保守治疗。
[Abstract]:Pus storage in dogs is one of the common obstetrical diseases in pet clinic. The nutritional status, epidemiology, hematology, imaging, histopathology, intrauterine microorganism culture, drug sensitivity test and treatment of 22 dogs with sepsis were studied. In order to provide reference and basis for clinical comprehensive diagnosis and treatment of uterine pus storage. The study showed that infertile dogs over 6 years of age were susceptible to sepsis. Variety, immune status and nutritional status were not correlated with the disease. The clinical manifestations of the dogs are depression, thirst, vomiting, diarrhea, abdominal enlargement, redness of the vulva, vaginal discharge of odorous secretions, elevated or decreased body temperature, paleness of the visible mucosa, and so on. The results of hematological examination showed that leukopenia appeared in dogs, the highest value was above 3 times of normal value, neutrophilic granulocyte and infantile leukocyte were increased to more than 80%, anemia was found in dogs with long course of disease. There is leukopenia in dogs with septicemia and normal hemogram in a few dogs. Most of the dogs had different degrees of renal and liver dysfunction, the common blood urea nitrogen (BUN) increased to more than 12mmol/l, the lactate dehydrogenase (LDH) was more than 328iu / l, the glutamic oxaloacetic transaminase (AST) was more than 41 IU / l. The total bilirubin was 6 times as high as the normal value, indicating that there was a certain degree of liver and kidney dysfunction in the affected dogs. The shape, size and location of the suppurative uterus were usually observed by B-ultrasonography. Histopathological sections of the diseased canine showed that most lesions showed no signs of tumor growth. Persistent corpus luteum or polycystic follicles were found in ovary and granulocytoma or papillary adenoma were found in some dogs. The common uterine wall thinning, endometrial atrophy or ulceration in atresia type dogs, and cystic endometrial hyperplasia and endometritis were more common in open type dogs, which suggested that atresia type was more serious than open type uterine pus storage type. Bacteria were isolated from 22 dogs, some of which were normal bacteria in the uterus. The main pathogenic bacteria were Escherichia coli (77.27%) and 尾 -hemolytic streptococcus (13.64%), the rest were Staphylococcus and Bacillus. The results showed that Escherichia coli was the main pathogen causing uterine pus, and its sensitivity to kanamycin and neomycin was the highest, reaching 100%. According to the results of clinical symptoms, hematological examination, imaging examination and bacterial isolation drug sensitivity test, 22 dogs were cured with different treatment methods. Among them, 6 dogs were treated with conservative therapy, accounting for 27.27% of the total number of cured dogs, and 16 cases were treated with surgical therapy, accounting for 72.73% of the total number of cured dogs. Up to now, total ovariectomy is still the first choice for the treatment of suppuration. For dogs with important breeding value or other reasons which can not be operated on, we can consider the use of uterine washing, combined with intrauterine bacterial drug sensitivity test to take targeted conservative treatment, such as antibacterial and anti-inflammatory.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：S858.292
本文编号：2397400
[Abstract]:Pus storage in dogs is one of the common obstetrical diseases in pet clinic. The nutritional status, epidemiology, hematology, imaging, histopathology, intrauterine microorganism culture, drug sensitivity test and treatment of 22 dogs with sepsis were studied. In order to provide reference and basis for clinical comprehensive diagnosis and treatment of uterine pus storage. The study showed that infertile dogs over 6 years of age were susceptible to sepsis. Variety, immune status and nutritional status were not correlated with the disease. The clinical manifestations of the dogs are depression, thirst, vomiting, diarrhea, abdominal enlargement, redness of the vulva, vaginal discharge of odorous secretions, elevated or decreased body temperature, paleness of the visible mucosa, and so on. The results of hematological examination showed that leukopenia appeared in dogs, the highest value was above 3 times of normal value, neutrophilic granulocyte and infantile leukocyte were increased to more than 80%, anemia was found in dogs with long course of disease. There is leukopenia in dogs with septicemia and normal hemogram in a few dogs. Most of the dogs had different degrees of renal and liver dysfunction, the common blood urea nitrogen (BUN) increased to more than 12mmol/l, the lactate dehydrogenase (LDH) was more than 328iu / l, the glutamic oxaloacetic transaminase (AST) was more than 41 IU / l. The total bilirubin was 6 times as high as the normal value, indicating that there was a certain degree of liver and kidney dysfunction in the affected dogs. The shape, size and location of the suppurative uterus were usually observed by B-ultrasonography. Histopathological sections of the diseased canine showed that most lesions showed no signs of tumor growth. Persistent corpus luteum or polycystic follicles were found in ovary and granulocytoma or papillary adenoma were found in some dogs. The common uterine wall thinning, endometrial atrophy or ulceration in atresia type dogs, and cystic endometrial hyperplasia and endometritis were more common in open type dogs, which suggested that atresia type was more serious than open type uterine pus storage type. Bacteria were isolated from 22 dogs, some of which were normal bacteria in the uterus. The main pathogenic bacteria were Escherichia coli (77.27%) and 尾 -hemolytic streptococcus (13.64%), the rest were Staphylococcus and Bacillus. The results showed that Escherichia coli was the main pathogen causing uterine pus, and its sensitivity to kanamycin and neomycin was the highest, reaching 100%. According to the results of clinical symptoms, hematological examination, imaging examination and bacterial isolation drug sensitivity test, 22 dogs were cured with different treatment methods. Among them, 6 dogs were treated with conservative therapy, accounting for 27.27% of the total number of cured dogs, and 16 cases were treated with surgical therapy, accounting for 72.73% of the total number of cured dogs. Up to now, total ovariectomy is still the first choice for the treatment of suppuration. For dogs with important breeding value or other reasons which can not be operated on, we can consider the use of uterine washing, combined with intrauterine bacterial drug sensitivity test to take targeted conservative treatment, such as antibacterial and anti-inflammatory.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：S858.292
【参考文献】
相关期刊论文 前9条
1 董美荣;;犬子宫蓄脓的手术疗法及体会[J];中国畜牧兽医文摘;2014年11期
2 韩素珍;周天红;蒋书东;潘孝成;;犬子宫蓄脓的影像诊断和手术治疗的研究[J];农技服务;2008年03期
3 董龙;金艺鹏;刘伟;林德贵;;犬子宫积脓厌氧菌调查及动物模型的建立[J];中国兽医杂志;2007年05期
4 秦亮;;浅谈子宫内膜炎与子宫积脓症的防治[J];乳业科学与技术;2006年04期
5 钱存忠;侯加法;;犬子宫蓄脓的病因学及病理变化特征[J];畜牧与兽医;2005年09期
6 李德印,石冬梅;犬子宫蓄脓症诊疗方法的实践与探讨[J];河南畜牧兽医;2004年10期
7 杨晓农,邓一科,刘群,岳华,罗薇;老龄犬子宫蓄脓的诊断和手术治疗[J];西南民族大学学报(自然科学版);2003年04期
8 李发志,刘学旭,向乾雄;犬子宫蓄脓症的诊断与手术[J];中国兽医杂志;2000年11期
9 陈兆英,张成林,张一国;超声断层扫描在兽医临床的初步应用[J];黑龙江畜牧兽医;1996年12期
，本文编号：2397400
本文链接：https://www.wllwen.com/yixuelunwen/dongwuyixue/2397400.html
