山东省鸡源性大肠杆菌耐药变化趋势监测

发布时间：2019-04-12 15:37

【摘要】：本研究旨在了解山东省鸡大肠杆菌耐药变化趋势,以期指导临床用药。采用96点阵药敏检测法,测定从临床上分离鉴定的2008-2014年山东省不同地区鸡场的210株大肠杆菌对14种抗生素的耐药性。结果显示,鸡源大肠杆菌对14种抗生素中的13种(多西霉素除外)的耐药性在这7年间有所增长,其中对10种抗生素的耐受性在7年间近乎翻了1倍甚至更高。根据监测结果,建议在山东地区暂停使用头孢噻呋治疗鸡大肠杆菌病,推荐使用多西霉素、大观霉素、硫酸粘菌素,将庆大霉素、新霉素、环丙沙星、恩诺沙星、氟苯尼考作为次级药物使用,并适当加大用量,应谨慎使用喹诺酮类药物和氟苯尼考。
[Abstract]:The purpose of this study was to understand the trend of resistance to Escherichia coli in chickens in Shandong Province, in order to guide the clinical use of the drug. The drug resistance of 210 Escherichia coli strains isolated from different chicken farms in Shandong Province from 2008 to 2014 to 14 antibiotics was determined by 96 dot-matrix drug sensitivity test. The results showed that the resistance of Escherichia coli from chicken to 13 of 14 antibiotics (except doxycycline) increased in the last seven years, and the tolerance to 10 antibiotics almost doubled or even higher in 7 years. Based on the monitoring results, it is recommended to suspend the use of cefotafur in the treatment of chicken colibacillosis in Shandong area, recommend the use of doxycycline, macromycin, colistin sulfate, gentamicin, neomycin, ciprofloxacin, enrofloxacin, Quinolones and flufenicol should be used cautiously when used as secondary drugs and increased dosage.
【作者单位】：山东省农业科学院家禽研究所;山东昊泰科技药业有限公司;
【基金】：山东省重点研发计划资助项目(2015GNC113004) 山东省农业重大应用技术创新资助项目([2013]136号) 山东省青年自然科学基金资助项目(ZR2012CQ042) 山东省现代农业产业技术体系资助项目(SDAIT-13-011-01)
【分类号】：S852.61

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