细菌鞭毛运动、黏附和免疫逃逸机制的研究进展

发布时间：2019-07-02 11:08

【摘要】：鞭毛是细菌表面重要的附属结构之一,很长一段时间以来被认为仅负责细菌的运动。然而随着对鞭毛的结构以及致病性深入研究发现,鞭毛的运动性能够促进细菌与宿主的相互作用,鞭毛介导的黏附在几种动植物病原体对宿主的定植过程中起很重要作用,而促进鞭毛结合到不同宿主组织的特异性互作机制至今仍不清楚。鞭毛素单体的保守区是机体先天性免疫应答的有效诱导剂,能够诱导机体发生免疫应答,然而细菌也进化出多重策略来逃避免疫识别。现对近年来细菌鞭毛在动植物宿主环境中的作用作一综述,为更全面认识和研究鞭毛提供参考。
[Abstract]:Flagellum is one of the important attached structures on the surface of bacteria, which has been thought to be only responsible for bacterial movement for a long time. However, with the further study of flagellum structure and pathogenicity, it is found that flagellum motility can promote the interaction between bacteria and host. Flagellum mediated adhesion plays an important role in the colonization process of several animal and plant pathogens to host, but the specific interaction mechanism of promoting flagellum binding to different host tissues is still unclear. The conserved region of flagellin monomer is an effective inducer of innate immune response, which can induce immune response. However, bacteria have evolved multiple strategies to avoid immune recognition. In this paper, the role of bacterial flagellum in animal and plant host environment in recent years is reviewed, which provides a reference for more comprehensive understanding and study of flagellum.
【作者单位】：扬州大学兽医学院;江苏省动物重要疫病与人兽共患病防控协同创新中心;
【基金】：国家自然科学基金资助项目(30571374,30771603,31072136,31270171) 江苏高校优势学科建设工程资助项目科技部转基因生物新品种培育重大专项资助项目(2014ZX08006-001B) 国家农业部“948”计划重点资助项目(2011-G24)
【分类号】：S852.61

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