鸭致病性大肠杆菌研究进展

发布时间：2019-07-02 14:07

【摘要】：近年来,由禽致病性大肠杆菌(avian pathogenic Escherichia coli,APEC)引起的禽大肠杆菌病给全球的养禽行业造成了重大的经济损失,并且APEC引起的禽大肠杆菌病在中国是最主要的家禽细菌病。越来越多的证据显示,APEC是人源尿路感染大肠杆菌(uropathogenic Escherichia coli,UPEC)和致脑膜炎大肠杆菌(neonatal meningitis Escherichia coli,NMEC)的毒力基因储藏库,甚至可能会直接导致两种疾病的发生。因此,如何有效地控制APEC不仅是一个紧迫的问题,更是一个巨大的挑战。对APEC的分离鉴定、流行病学特征、药物敏感性等内容的研究对APEC引起的禽大肠杆菌病的控制具有指导意义。为了更好地防控大肠杆菌病,文章主要从临床症状、病理变化、毒力因子、致病机理和诊断方法几个方面对鸭致病性大肠杆菌进行了综述,以期为进一步研究提供参考。
[Abstract]:In recent years, avian colibacillosis caused by avian pathogenic Escherichia coli (avian pathogenic Escherichia coli,APEC) has caused great economic losses to the global poultry industry, and avian colibacillosis caused by APEC is the most important bacterial disease in poultry in China. More and more evidence suggests that APEC is a repository of virulence genes for human urinary tract infection with E. coli (uropathogenic Escherichia coli,UPEC) and meningitic Escherichia coli (neonatal meningitis Escherichia coli,NMEC), which may even directly lead to the occurrence of the two diseases. Therefore, how to effectively control APEC is not only an urgent problem, but also a great challenge. The isolation and identification of APEC, epidemiological characteristics and drug sensitivity are of guiding significance for the control of avian colibacillosis caused by APEC. In order to prevent and control colibacillosis better, the pathogenic Escherichia coli of duck was reviewed from the aspects of clinical symptoms, pathological changes, virulence factors, pathogenic mechanism and diagnostic methods, in order to provide reference for further study.
【作者单位】：中国农业科学院哈尔滨兽医研究所/兽医生物技术国家重点实验室;牡丹江师范学院生命科学与技术学院;
【基金】：“十二五”国家科技支撑计划项目(2015BAI07B02-02)
【分类号】：S852.612

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