Electroacupuncture Provides Analgesia in Combination with De

发布时间：2023-03-27 02:58

　　针灸是古代中国的医疗精粹,用于治疗各种疾病和症状长达2000多年。针灸目前已经在全世界范围内广泛流行,许多对传统疗法耐受的疾病,运用针灸进行治疗,取得了显著效果。同时针灸克服了药物疗法的副作用。针灸吸引了大量的基础研究者观察其对人和动物的镇痛效果,并研究这种神奇疗效背后的机制。针灸为治疗疼痛提供了一种显著又安全的方法,这使得针灸在兽医中快速发展。美国动物医院协会和美国猫科动物从业者协会联合发布了犬猫疼痛管理的条例,该条例指出,越来越多有力的证据表明针灸疗法已成为兽医普遍接受的治疗疼痛性疾病的方式。1.电针结合肌肉注射右旋美托咪啶镇痛对山羊生理生化的影响。试验目的：研究电针结合右旋美托咪啶对山羊镇痛效果及对生理生化的影响。试验动物：30只杂交健康雌性山羊。试验方法：山羊随机分成5组：电针组,两种剂量的右旋美托咪啶(5和20μg/kg, IM),电针加右旋美托咪啶(5μg/kg,IM)和对照组(0.9%NaCl,IM)。检测痛阈、心肺功能、直肠温度和血液及生化指标。试验结果：右旋美托咪啶(20μ/kg)可以提高山羊痛阈、降低心律、呼吸频率和指肠温度。与电针组30min后和右旋美托咪啶组(5...

【文章页数】：103 页

【学位级别】：博士

【文章目录】：
摘要
Abstract
Abbreviations
Chapter 1.Introduction
    1.1 Acupuncture Analgesia
    1.2 Alpha2 agonists and its application in Small Ruminants
        1.2.1 Alpha2 adrenoceptor subtypes and their agonists
        1.2.2 Uses of alpha2 adrenergic agonists
            1.2.2.1 Sedative effects
            1.2.2.2 Analgesic effects
            1.2.2.3 Anesthetic sparing effects
        1.2.3 Side effects of alpha2 agonists
            1.2.3.1 Cardiovascular effects
            1.2.3.2 Respiratory effects
            1.2.3.3 Other side effects of alpha2 agonists
        1.2.4 Antagonism
    1.3 Acupuncture-drug balanced analgesia
    1.4 The mitogen-activated protein kinases
        1.4.1 Extracellular signal regulated kinases
        1.4.2 Phosphorylation of Extracellular signal regulated kinases
        1.4.3 ERK and pain
            1.4.3.1 Activation of ERKs in primary afferent neurons
            1.4.3.2 Activation of ERKs in spinal cord neurons
            1.4.3.3 Activation of ERKs in the brain
    1.5 Objectives of the proposed research
        1.5.1 Objective-1:(program-1)
        1.5.2 Objectives-2:(program-2)
Chapter 2.Physiological and biochemical effects of electroacupuncture combined withintramuscular administration of dexmedetomidine to provide analgesia in goats
    2.1 Materials and methods
        2.1.1 Animal preparation
        2.1.2 Experimental design
        2.1.3 Electroacupuncture
        2.1.4 Physiologic variables
        2.1.5 Hematological and biochemical parameters
        2.1.6 Statistical analysis
    2.2 Results
        2.2.1 Sedative and analgesic effects
        2.2.2 Cardiorespiratory functions and rectal temperatures
        2.2.3 Biochemical and hematological parameters
    2.3 Discussion
Chapter 3.Effect of Electroacupuncture on Activation of ERK1/2-IR cells in the CentralNervous System of Rats with Inflammatory Pain
    3.1 Material and Method
        3.1.1 Animals and grouping
        3.1.2 Eletroacupuncture treatment
        3.1.3 Measurement of paw volume
        3.1.4 Paw withdrawal thresholds
        3.1.5 Immunohistochemistry
        3.1.6 Statistical analysis
    3.2 Results
        3.2.1 Effects of EA on CFA induced Paw Edema in Rats
        3.2.2 Effects of EA on CFA induced PWTs in Rats
        3.2.3 Effect of EA on Phosphor-pERK1/2-Immunoreactivity(pERK1/2-IR) Expression in the Spinal Dorsal Horn in CFA Rats
        3.2.4 Effect of EA on Phosphor-pERK1/2-Immunoreactivity(pERK1/2-IR) Expression in the NRM and GiA Nuclei or area in CFA Rats
        3.2.5 Effect of EA on Phosphor-pERK1/2-Immunoreactivity(pERK1/2-IR) Expression in the Gi nucleus or area in CFA Rats
    3.3 Discussion
4 Conclusions
References
Immunohistochemistry Pictures
Acknowledgements
Dedications
Appendix



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