新生儿高胆红素血症相关影响因素分析

发布时间：2018-01-11 08:18

本文关键词：新生儿高胆红素血症相关影响因素分析　出处：《新疆医科大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：探讨新生儿高胆红素血症（高胆）相关影响因素，为临床预防及治疗新生儿高胆红素血症提供临床依据。方法：调查2011—2012年新疆医科大学第一附属医院5023例新生儿（产科新生儿4442例及新生儿科高胆红素血症病例581例），进行回顾性及描述性分析，根据Logistic回归分析其影响因素。结果：1.二分类Logistic回归分析示：民族、胎龄、出生体重为新生儿高胆红素血症保护因素（P0.05，β均0，分别为-0.387、-0.446、-1.011,exp(β)均1，分别为0.473、0.246、0.016）;胎膜早破、头颅血肿、喂养方式、母子血型不合、开奶时间、同胞中有高胆红素血症为新生儿高胆红素血症危险因素（P0.05，β均0,分别为0.334、0.346、0.889、0.591、0.476、1.889，,exp(β)均1，1.715、1.413、2.434、1.453、1.460、1.843）。2.将新生儿高胆红素血症作为研究组，分为轻中度组、重度组，对照组为非高胆红素血症新生儿，进行多元Logistic分析显示：胎龄和出生体重为新生儿高胆红素血症保护性因素（P0.05,β均0,分别为-0.443、-1.011，exp(β)均1，分别为0.441、0.016），母子血型不合、开奶时间、同胞中高胆红素血症、胎膜早破为其病情严重程度的危险因素（P0.05,β均0,分别为1.673、1.361、1.657、0.452，exp(β)均1，分别为1.673、1.361、2.113、1.822）；3.民族中维族、哈族新生儿高胆红素血症发病率低（P0.05），喂养方式中人工及混合喂养较母乳喂养新生儿高胆红素血症发病率低（P0.05）；结论：新生儿高胆红素血症是新生儿常见疾病，发病率高，与多种相关因素有关，根据相关危险因素积极治疗制定诊治方案，积极预防感染，重视产前相关检查及生后胆红素监测，，减少高胆发病率，尤其重症高胆红素血症发病率，降低高胆红素血症对新生儿生长发育影响。
[Abstract]:Objective: to investigate the related factors of neonatal hyperbilirubinemia (hyperbilirubinemia). Methods: a survey of 5023 neonates with neonatal hyperbilirubinemia in the first affiliated Hospital of Xinjiang Medical University from 2011 to 2012 was conducted to provide clinical evidence for the prevention and treatment of neonatal hyperbilirubinemia. 4442 cases of obstetrical newborns and 581 cases of neonatal hyperbilirubinemia. Retrospective and descriptive analysis were carried out. According to the Logistic regression analysis, the influencing factors were analyzed. Results the Logistic regression analysis showed that: nationality, gestational age. Birth weight was the protective factor of neonatal hyperbilirubinemia (P0.05, 尾 0, respectively, -0.387- 0.446- 1.011exp1). It was 0.473U (0.246) and 0.016m (P < 0.05). Premature rupture of membranes, cranial hematoma, feeding mode, blood group incompatibility between mother and child, time of milk opening, hyperbilirubinemia in sibling were risk factors of hyperbilirubinemia in newborn (P 0.05, 尾 0). The values were 0.334U 0.346U 0.889U 0.591U 0.476U 1.889U expp (尾) 1.715U 1.413132.434, respectively. The neonatal hyperbilirubinemia was divided into mild and moderate group, severe group, and control group as non-hyperbilirubinemia neonates. Multivariate Logistic analysis showed that gestational age and birth weight were the protective factors of neonatal hyperbilirubinemia (P0.05, 尾 0, respectively, -0.443 卤1.011). Expat (尾) were 1, respectively, were 0.441 ~ 0.016, blood group incompatibility, milk opening time, sibling hyperbilirubinemia. Premature rupture of membranes was the risk factor for the severity of the disease (P 0.05, 尾 = 0, respectively, 1.673U 1.361U 1.657U 0.452exp1). 1.673U 1.361C 2.113U 1.822m; 3.The incidence of neonatal hyperbilirubinemia in Uygur and Kazakh nationalities was lower than that in breast-fed neonates (P 0.05), and the incidence of hyperbilirubinemia was lower in artificial and mixed feeding than in breast-fed neonates. Conclusion: neonatal hyperbilirubinemia is a common disease of newborns with high incidence, which is related to many related factors. According to the related risk factors, active treatment and diagnosis and treatment are made to prevent infection. To reduce the incidence of hyperbilirubinemia, especially severe hyperbilirubinemia, and reduce the influence of hyperbilirubinemia on the growth and development of newborn, we should pay attention to prenatal examination and postnatal bilirubin monitoring.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R722.1

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