198例新生儿败血症病原学与耐药性分析

发布时间：2018-01-26 10:14

本文关键词： 新生儿败血症致病菌药敏　出处：《中华医院感染学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的了解医院新生儿败血症菌群分布和细菌耐药情况,为临床医生合理使用抗菌药物提供参考依据。方法回顾性分析2014年1月-2016年12月医院分娩时诊断为败血症,且血培养阳性的198例新生儿的基本资料和血培养结果进行统计分析;采用x2检验分析不同组别之间的临床基本特征差异。结果医院198例新生儿败血症的血液标本培养分离出病原菌263株,其中革兰阳性菌228株,占86.7%,且以凝固酶阴性葡萄球菌(MRCNS)为主,其对青霉素G、红霉素、克林霉素、磺胺甲VA唑/甲氧苄啶有较高的耐药性;革兰阴性菌检出19株,占7.2%,对亚胺培南、阿米卡星的耐药率较低;真菌检出16株,占6.1%,仅一株耐药菌。结论在新生儿败血症的治疗过程中,要特别注意凝固酶阴性葡萄球菌引起的败血症,定期对医院常见病原菌耐药性进行分析,根据其药敏情况合理地选择抗菌药物。
[Abstract]:Objective to investigate the distribution of bacterial flora and drug resistance of neonatal septicemia in hospital. Methods the diagnosis of septicemia in hospital from January 2014 to December 2016 was analyzed retrospectively. The basic data of 198 newborns with positive blood culture and the results of blood culture were analyzed statistically. Results 263 strains of pathogenic bacteria were isolated from blood samples of 198 neonates with septicemia in hospital, of which 228 were Gram-positive bacteria. The drug resistance of MRCNS to penicillin G, erythromycin, clindamycin, sulfamethazol / trimethoprim was higher. 19 strains of Gram-negative bacteria were detected, accounting for 7.2%. The drug resistance rate to imipenem and amikacin was low. 16 strains of fungi were detected, accounting for 6.1%, and only one strain was drug-resistant. Conclusion in the treatment of neonatal septicemia, special attention should be paid to the septicemia caused by coagulase negative staphylococcus. The antimicrobial resistance of common pathogens in hospital was analyzed regularly, and the antimicrobial agents were selected reasonably according to their drug sensitivity.
【作者单位】：浙江大学医学院附属妇产科医院院感科;杭州市疾病预防控制中心环境所;
【基金】：杭州市医学重点专科专病基金资助项目(20130733Q32)
【分类号】：R722.131
【正文快照】： 新生儿败血症是新生儿感染性疾病中较常见的疾病,是指细菌或真菌在新生儿期侵入血液循环,并在血液中生长繁殖、产生毒素,从而引发全身性感染症状[1]。国外流行病学调查显示,每1000个新生儿出生,其中就有1~5人会发生败血症[2]。在我国,新生儿败血症的发病率约占出生婴儿的l‰~1

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