反复肺炎患儿血清YKL-40与体液免疫功能的变化及意义

发布时间：2018-01-29 11:28

本文关键词： 反复肺炎 YKL- 体液免疫功能儿童　出处：《中国当代儿科杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的研究反复肺炎患儿血清YKL-40与体液免疫功能的变化及意义。方法收集30例反复肺炎患儿(反复肺炎组)、30例急性肺炎患儿(急性肺炎组)、30例健康体检儿童(对照组)的血标本,采用酶联免疫吸附法检测各组血清YKL-40浓度。并进行血清YKL-40与体液免疫相关实验室指标的相关性分析。利用受试者工作特征(ROC)曲线分析血清YKL-40对反复肺炎的诊断价值。结果反复肺炎组血清YKL-40浓度高于急性肺炎组及对照组(P0.05),急性肺炎组血清YKL-40浓度高于对照组(P0.05)。反复肺炎组血清Ig G和补体C4水平均低于急性肺炎组(P0.05)。血清YKL-40浓度与Ig G水平呈负相关(r_s=-0.309,P=0.047),与补体C4水平亦呈负相关(r=-0.324,P=0.039)。血清YKL-40诊断反复肺炎的ROC曲线下面积为0.958(95%CI:0.921~0.994)。结论反复肺炎患儿体液免疫功能降低;血清YKL-40可能参与了反复肺炎的发生,并可作为反复肺炎诊断的参考指标。
[Abstract]:Objective to study the changes and significance of serum YKL-40 and humoral immune function in children with recurrent pneumonia. Blood samples of 30 healthy children (control group). Enzyme linked immunosorbent assay (Elisa) was used to detect the concentration of serum YKL-40 in each group, and the correlation between serum YKL-40 and humoral immune-related laboratory indexes was analyzed. Results the serum YKL-40 concentration in recurrent pneumonia group was higher than that in acute pneumonia group and control group (P 0.05). The serum YKL-40 concentration in acute pneumonia group was higher than that in control group (P 0.05), and the levels of serum IgG and complement C4 in recurrent pneumonia group were lower than those in acute pneumonia group (P 0.05). There was a negative correlation between serum YKL-40 concentration and IgG level. There was also a negative correlation between the level of complement C4 and the level of Pt0. 047, and a negative correlation with the level of complement C4. The area under the ROC curve of serum YKL-40 for the diagnosis of recurrent pneumonia is 0.958% 95% CI: 0.921 1 0.994). Conclusion the humoral immune function of children with recurrent pneumonia is decreased. Serum YKL-40 may be involved in the occurrence of recurrent pneumonia and can be used as a reference index for the diagnosis of recurrent pneumonia.
【作者单位】：郑州大学第一附属医院儿科;
【分类号】：R725.6
【正文快照】： 肺炎是小儿常见病,是住院患儿死亡的主要原因之一,部分患儿可反复多次发生肺炎[1]。反复肺炎是指1年内反复患肺炎≥2次,肺炎由肺部体征和影像学证实,两次肺炎诊断期间肺炎体征和影像学改变应完全消失[2]。反复肺炎对某些群体的小儿有着重要的临床现实意义,及时检出高危患儿并

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