参麻颗粒治疗小儿风寒感冒的临床研究

发布时间：2018-02-01 02:27

本文关键词： 小儿风寒感冒中医治疗临床研究急性毒性实验　出处：《云南中医学院》2014年硕士论文　论文类型：学位论文

【摘要】：目的：本文通过对参麻颗粒治疗小儿风寒感冒的疗效进行系统观察和研究，探讨该方的作用机制，，并通过急性毒性实验对参麻颗粒的安全性进行初步评价，以寻求中医药治疗小儿风寒感冒的新思路。方法:（1）本研究采用随机单盲法将符合诊断标准的60例风寒感冒患儿用数字随机分组法分为参麻颗粒组（观察组）和风寒感冒颗粒组（对照组）,观察组与对照组各30例，治疗1-2个疗程（3～6天），观察并对比两组患儿服药后症状、体征的量化评分的改变情况，进行综合疗效评定。（2）急性毒性实验在不能求得半数致死量的情况下，采用最大耐受量法求得小鼠1日的最大耐受量。结果:（1）在总的疗效比较方面，观察组与对照组疗效相当,差异无统计学意义(P0.05)。在改善临床症状方面，观察组对咳嗽等症状的改善优于对照组。（2）急性毒性实验求得小鼠1日最大耐受量为生药8.932g/kg，相当于成人全日临床推荐量的32.48倍，提示参麻颗粒临床用药安全。结论:通过对参麻颗粒的临床研究及急性毒性实验，证明参麻颗粒治疗小儿风寒感冒疗效肯定，且该药物无明显毒副作用，值得推广和应用。
[Abstract]:Objective: to observe and study the therapeutic effect of Shenma granule on children with wind-cold colds, to explore the mechanism of its action, and to evaluate the safety of Shenma granule through acute toxicity experiment. In order to seek traditional Chinese medicine to treat children with cold cold new ideas. Methods in this study, 60 children with wind-cold cold were randomly divided into Shenma granule group (observation group) and wind cold cold granule group (control group) by random single blind method. There were 30 cases in the observation group and 30 cases in the control group, who were treated with 1-2 courses of treatment for 3 days or 6 days. The changes of the quantitative scores of symptoms and signs of the two groups were observed and compared. In the acute toxicity test, the maximum tolerance dose of mice in 1st was obtained by using the method of maximum tolerance dose under the condition that half lethal dose could not be obtained. Results compared with the control group, the curative effect of the observation group was similar to that of the control group, but the difference was not statistically significant (P 0.05). The improvement of cough and other symptoms in the observation group was better than that in the control group. (2) Acute toxicity test showed that the maximum tolerance dose in 1st was 8.932 g / kg crude drug. It is 32. 48 times that of adult clinical recommendation, suggesting that Shenma granule is safe in clinical use. Conclusion: through the clinical study and acute toxicity experiment of Shenma granule, it is proved that Shenma granule is effective in treating cold in children, and it has no obvious side effects, so it is worth popularizing and applying.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R272

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