儿童维生素A缺乏与血红蛋白水平及呼吸道感染相关性研究

发布时间：2018-02-05 22:41

本文关键词： 维生素A 缺乏症呼吸道感染血红蛋白　出处：《临床儿科杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的了解健康儿童和伴有呼吸道感染症状儿童维生素A营养状况,及其与血红蛋白水平的相关性。方法纳入2014年12月至2015年8月期间在北京居住半年以上的健康体检儿童,检测血清视黄醇、外周血血红蛋白水平,分析维生素A营养状况与年龄、呼吸道感染及贫血的关系。结果共纳入1 742例儿童,男1 056例、女686例,中位年龄3.1岁(6个月~17岁);就诊时有呼吸道感染症状儿童202例,无呼吸道感染症状儿童1 540例。受检儿童的血清视黄醇中位水平0.29 mg/L(0.25~0.33 mg/L),有呼吸道感染症状儿童低于无呼吸道症状儿童,差异有统计学意义(P0.001)。亚临床维生素A缺乏、可疑亚临床缺乏比例分别为5.8%和47.9%;9岁儿童的亚临床及可疑亚临床缺乏比率均50%,不同年龄组的亚临床和可疑亚临床缺乏比例的差异有统计学意义(P0.001)。亚临床维生素A缺乏、可疑亚临床缺乏及正常组儿童的贫血发生率分别为3.9%、8.7%、10.8%,差异有统计学意义(P0.01)。血清视黄醇、血红蛋白浓度与年龄均呈正相关(r=0.179、0.571,P均0.001);血清视黄醇与血红蛋白浓度呈正相关(r=0.244,P0.001)。结论呼吸道感染儿童血清视黄醇水平低于健康儿童,维生素A缺乏与贫血发生相关。
[Abstract]:Objective to investigate the vitamin A nutritional status of healthy children and children with respiratory tract infection. Methods healthy children who lived in Beijing for more than half a year from December 2014 to August 2015 were included in this study to detect serum retinol. The level of hemoglobin in peripheral blood and the relationship between vitamin A nutritional status and age, respiratory tract infection and anemia were analyzed. Results 1 742 children (1 056 males and 686 females) were included. The median age was 3.1 years (6 months and 17 years old); 202 children with respiratory tract infection symptoms. There were 1 540 children with no symptoms of respiratory tract infection. The median level of retinol was 0.29 mg/L(0.25~0.33 mg / L in the tested children. Children with respiratory tract infection symptoms were lower than those without respiratory symptoms, the difference was statistically significant (P 0.001). Subclinical vitamin A deficiency. The rates of suspected subclinical deficiency were 5.8% and 47.9 respectively. The subclinical and suspected subclinical deficiency rates of children aged 9 years were 50%. There was significant difference between subclinical and suspected subclinical deficiency rates in different age groups (P 0.001). The incidence of anemia in the children with suspected subclinical deficiency and normal children was 3.9 / 8.7 and 10.8, respectively. The difference was statistically significant (P 0.01). There was a positive correlation between hemoglobin concentration and age. There was a positive correlation between serum retinol and hemoglobin concentration. Conclusion the level of serum retinol in children with respiratory tract infection is lower than that in healthy children, and vitamin A deficiency is associated with anemia.
【作者单位】：首都儿科研究所儿童保健科;北京李桥儿童医院综合科;民航总医院儿科;北京房山区妇幼保健院儿童保健科;北京平谷区妇幼保健院儿科;北京石景山区妇幼保健院儿童保健科;北京怀柔医院儿科;北京和合医学诊断技术股份有限公司中心实验室;清华大学玉泉医院儿科;
【基金】：国家卫生计生委科技发展中心临床科研专项课题(No.W2015EAE001)
【分类号】：R723.2

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