儿童甲状腺大小与影响因素的相关性研究

发布时间：2018-02-05 23:15

本文关键词： 儿童年龄性别尿碘甲状腺　出处：《河北医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:本研究旨在探讨性别、甲状腺功能、年龄、尿碘结果、甲状腺结合球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)对儿童甲状腺大小的影响。方法:研究对象为自2013年01月至2014年12月因颈部不适而就诊我院儿科生长发育内分泌门诊的110名患儿,严格按照纳入标准进行筛选,记录患儿就诊时间,性别,年龄,尿碘结果,甲状腺B超结果,甲状腺功能检查结果,甲状腺结合球蛋白抗体(TGAb),甲状腺微粒体抗体(TMAb)。全部数据的统计学处理均使用SPSS17.0统计软件。计数资料采用卡方检验或者Fisher确切概率法进行检验;计量资料,符合正态分布的可采用均数±标准差表示,使用t检验、方差分析或k-w检验;不符合正态分布的可采用中位数、四分位数间距表示,使用独立样本非参数的秩和检验。P0.05认为差异具有统计学意义。结果:1不同性别儿童的甲状腺功能构成比不存在统计学差异,甲状腺各部分大小不存在统计学差异。2按照年龄,将研究对象分为如下3组:3~岁组,7~岁组,11~岁组。三组甲功结果构成比进行比较所得P=0.496,甲功结果构成无年龄差异;三组甲状腺大小进行比较,随年龄增长,左叶长度呈上升趋势,三组均具有统计学差异(P0.001);左叶宽度呈上升趋势,且第3组和第1、2组的差别具有统计学意义(P=0.003);左叶高度呈上升趋势,三组之间的差异具有统计学意义(P=0.002),第1、2组的左叶高度普遍低于第3组的左叶高度;随年龄增长,峡部厚度呈上升趋势,第1组低于第3组,第2组与其它两组之间暂不能认为有差异(P=0.027);右叶长度呈上升趋势,且三组之间的差异具有统计学意义(P0.001);右叶宽度呈上升趋势,第3组与第1、2组的差异有统计学意义(P=0.002);右叶高度呈上升趋势,第3组与第1、2组的差异具有统计学意义(P=0.001)。3根据甲功结果可分为:甲功低于正常组、甲功高于正常组、甲功正常组。左叶长度、左叶高度、峡部厚度、右叶长度、右叶宽度、右叶高度第3组低于第1、2组,差异具有统计学意义(P0.001);左叶宽度三组之间的差别暂不能认为具有统计学意义(P=0.234)。4根据尿碘结果分为:100ug/l组,300ug/l组,
[Abstract]:Objective: to investigate sex, thyroid function, age, urinary iodine results, thyroid binding globulin antibody (TGAb). Thyroid microsomal antibody TMAb). Methods: from January 2013 to December 2014, 110 children with neck discomfort were selected from pediatric growth and development endocrine clinic in our hospital. According to the inclusion criteria, the time of visit, sex, age, urine iodine, thyroid B ultrasound, thyroid function, thyroid binding globulin antibody TGAbwere recorded. All the data were processed by SPSS17.0 software. The counting data were checked by chi-square test or Fisher exact probability method. The measurement data can be expressed by mean 卤standard deviation, t test, ANOVA or k-w test. The nonconforming normal distribution can be expressed as median, quartile spacing. The results showed that there was no statistical difference in the thyroid function composition ratio of children with different sex of 1: 1 using rank sum test (P0.05) of independent sample. There was no statistical difference in the size of each part of thyroid. 2. According to age, the study subjects were divided into three groups: 3: 3 years old group and 7 ~-year old group. The composition ratio of the results of A work in the three groups was 0.496, and there was no age difference between the results of the results of the results of A work and that of the three groups. The size of thyroid gland in the three groups was compared, and the length of Zuo Ye increased with age, and there was a statistical difference among the three groups (P 0.001). The width of Zuo Ye increased, and the difference between group 3 and group 1 was statistically significant. The height of Zuo Ye was on the rise, and the difference between the three groups was statistically significant. The height of Zuo Ye in group 1 and group 2 was generally lower than that in group 3. The thickness of isthmus increased with age, the thickness of isthmus in group 1 was lower than that in group 3, and there was no difference between group 2 and the other two groups. The length of right lobe was on the rise, and the difference between the three groups was statistically significant (P 0.001). The width of right lobe showed an increasing trend, and the difference between group 3 and group 1 was statistically significant. The height of right lobe showed an upward trend, and the difference between group 3 and group 1 was statistically significant. According to the results of nail work, it could be divided into two groups: the work of A was lower than that of normal group, and the work of A was higher than that of normal group. The length of Zuo Ye, the height of Zuo Ye, the thickness of isthmus, the length of right lobe, the width of right lobe and the height of right lobe in group 3 were lower than those in group 1 (P 0.001). The difference between the three groups of Zuo Ye's width cannot be regarded as statistically significant for the time being. According to the results of urine iodine, they can be divided into two groups: one is the 300ugr-1 group, and the other is the 300ugr-1 group.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.8

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