SLC1A3基因rs2269272位点多态性与中国青少年自杀未遂及非自杀性自伤的相关性

发布时间：2018-02-13 00:05

本文关键词： 自杀未遂非自杀性自伤 SLC1A3基因单核苷酸多态性　出处：《重庆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的探讨神经胶质高亲和性谷氨酸转运体(glial high-affinity glutamate transporter,SLC1A3)基因rs 2269272位点多态性(Single nucleotide polymorphisms,SNP)与中国青少年自杀未遂者及非自杀性自伤者发病及首发年龄和采取方式的相关性。方法采用iMLDRTM基因分型技术,对70例自杀未遂者,55例非自杀性自伤者和112例对照者(无自伤自杀行为)对SLC1A3基因rs2269272位点进行多态性检测,并应用生存分析研究危险等位基因(T)与自杀未遂及非自杀性自伤者首发年龄的相关性,分析自杀未遂者自杀方式与危险等位基因(T)的相关性。结果自杀未遂组与对照组相比,rs2269272位点等位基因及基因型频率分布的差异有统计学意义(χ2=6.093,P=0.014;χ2=8.388,P=0.015);非自杀性自伤组与对照组相比,rs2269272位点等位基因频率差异具有统计学意义(χ2=4.208,P=0.040),而基因型差异无统计学意义(χ2=4.011,P=0.135),自杀未遂患者携带危险等位基因(T)与不携带危险等位基因(T)首发年龄的差异有统计学意义(χ2=5.709,P=0.017);非自杀性自伤患者携带危险等位基因(T)与不携带危险等位基因(T)首发年龄的差异无显著统计学意义(χ2=0.516,P=0.473)。暴力自杀与非暴力自杀rs2269272基因型频率差异无统计学意义(χ2=5.369,P=0.068),等位基因频率差异具有统计学意义(χ2=4.251,P=0.039)。结论SLC1A3基因rs 2269272位点不仅是自杀未遂也是非自杀性自伤的易感基因,携带危险等位基因(T)的青少年可能更早自杀和采取暴力的方式自杀。
[Abstract]:Objective to investigate the association between glial high-affinity glutamate transporterus SLC1A3 (rs 2269272) polymorphism and the onset, onset age and mode of suicide in Chinese adolescents with attempted suicide and non-suicidal self-injury. Methods iMLDRTM genotyping technique was used. The polymorphism of rs2269272 locus of SLC1A3 gene was detected in 70 cases of attempted suicide and 55 cases of non-suicidal self-injured persons and 112 cases of controls (without suicide behavior). Survival analysis was used to study the correlation between the risk allele (T) and the onset age of suicide attempt and non-suicidal self-injury. Results there were significant differences in alleles and genotype frequencies of rs2269272 between attempted suicide group and control group (蠂 2 = 6.093, P = 0.014, 蠂 ~ 2 = 8.388, P = 0.015), non-suicidal self-injury group and control group, respectively. The allelic frequency of rs2269272 in the control group was significantly different (蠂 ~ 2 / 2 = 4.208), but there was no significant difference in genotype (蠂 ~ (2) = 4.011 / P ~ (0.135)). There was no significant difference in initial age between non-suicidal self-injured patients (蠂 ~ 2 / 5.709) and non-suicidal suicide patients (蠂 ~ 2 ~ (0.516) P ~ (0.473)). There was no significant difference in the frequency of rs2269272 genotypes between violent suicide and non-violent suicide. There was significant difference in allelic frequency (蠂 ~ 2 ~ 2 ~ (5.369) P ~ (0.068)) and allele frequency (蠂 ~ 2 ~ 2 ~ (4.251) P ~ (0.039)). Conclusion the rs _ s _ (2269272) locus of SLC1A3 gene is not only a suicide attempt but also a non-suicidal self-injury susceptibility gene. Adolescents with risk alleles may commit suicide earlier and commit violent suicide.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749;B846

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