吗啡联合炎琥宁注射液对重症手足口病合并中枢神经损伤患儿的疗效

发布时间：2018-03-06 04:38

本文选题：吗啡　切入点：手足口病　出处：《广东医学》2017年18期 　论文类型：期刊论文

【摘要】：目的观察吗啡联合炎琥宁注射液对手足口病合并中枢神经损伤患儿的临床疗效。方法收集临床确证的手足口病合并中枢神经损伤患儿92例,随机分为对照组(n=46)和观察组(n=46),对照组除了常规的退热、补液及补充维生素C之外给予炎琥宁注射液10 mg/(kg·d)加入100 m L 50 g/L葡萄糖溶液中进行静脉滴注;观察组在此基础上将盐酸吗啡(0.05 mg/kg)用5 m L生理盐水稀释后静脉推注,另将用50 g/L葡萄糖溶液稀释的盐酸吗啡以20μg/(kg·h)的速度匀速输注,1次/d,7 d为1个疗程,治疗结束后,分别对两组患儿的超敏C反应蛋白(hs-CRP)、脑源性神经营养因子(brain derived neurotrophic factor,BDNF)、神经元特异性烯醇化酶(2-phospho-D-glycerate hydrolase,NSE)、S-100β蛋白、内皮素-1(endothelin,ET-1)及神经肽Y(neuropeptide Y,NPY)的水平进行检测,统计分析检测结果。结果观察组患儿总显效率及痊愈率均高于对照组,差异有统计学意义(P0.05)。与对照组治疗后比较,观察组治疗后NSE、S-100β、BDNF、ET-1、NPY及hs-CRP显著降低(P0.05)。结论吗啡有利于手足口病合并神经损伤的恢复和改善。
[Abstract]:Objective to observe the clinical effect of morphine combined with Yanhuning injection on children with HFMD complicated with central nervous system injury. The control group was randomly divided into two groups: control group (n = 46) and observation group (n = 46). In addition to routine antipyretic, rehydration and vitamin C supplementation, the control group was given 10 mg/(kg 路d of Yanhuning injection (10 mg/(kg 路d) plus 100ml 50 g / L glucose solution for intravenous drip. On this basis, morphine hydrochloride 0.05 mg 路kg ~ (-1) was diluted with 5 mL normal saline and injected intravenously with 50 g / L dextrose solution of morphine hydrochloride at a speed of 20 渭 g / kg 路h) for 7 days as a course of treatment. The levels of hypersensitive C-reactive protein (hs-CRP), brain-derived neurotrophic factor (brain-derived neurotrophic factor) derived neurotrophic factor-BDNFN, neuron-specific enolase 2-phospho-D-glycerate hydrolase S-100 尾, endothelin 1 endothelin1 (et 1) and neuropeptide Y neuropeptide (YN) were measured in the two groups. Results the total effective rate and cure rate in the observation group were higher than those in the control group, and the difference was statistically significant (P 0.05). In the observation group, NSES-100 尾 -BDNFT-1NPY and hs-CRP decreased significantly (P 0.05). Conclusion morphine is beneficial to the recovery and improvement of hand, foot and mouth disease with nerve injury.
【作者单位】：许昌市第二人民医院儿科;
【分类号】：R725.1

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