生酮饮食治疗儿童全面性发育迟缓的前瞻性研究

发布时间：2018-03-18 07:02

本文选题：全面性发育迟缓　切入点：生酮饮食　出处：《中国当代儿科杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的观察生酮饮食(KD)对全面性发育迟缓(GDD)患儿神经行为发育、情绪和社会行为及生活能力的影响。方法采用前瞻性病例对照研究,对住院的GDD患儿随机分为KD治疗组和常规治疗组,最终常规治疗组37例和KD治疗组40例纳入研究。两组患儿均进行综合康复训练,KD治疗组在此基础上给予生酮饮食改良Atkins治疗方案。治疗前及治疗后3、6、9个月对两组患儿进行Gesell发育量表、中国幼儿情绪性及社会性发展量表(CITSEA)/Achenbach儿童行为量表(CBCL)、婴儿-初中学生社会生活能力量表(S-M量表)评估,比较2组之间神经行为发育、情绪和社会行为及生活能力的改善情况。结果治疗后3、6、9个月两组患儿Gesell评分比较,在适应性、精细动作、言语3个能区的评分,KD治疗组改善情况优于常规治疗组(P0.05);治疗后3、6、9个月两组患儿CITSEA/CBCL评分比较,KD治疗组改善情况亦优于常规治疗组(P0.05);治疗后9个月KD治疗组S-M量表评分改善情况优于常规治疗组(P0.05)。KD治疗期间,6例患儿出现腹泻症状,1例出现轻度泌尿系结石。结论 KD治疗可改善GDD患儿的神经行为发育及情绪和社会行为,且不良反应少。
[Abstract]:Objective to observe the effect of ketone diet on neurobehavioral development, emotion, social behavior and life ability in children with GDDs. Methods A prospective case-control study was conducted. The hospitalized children with GDD were randomly divided into KD treatment group and routine treatment group. In the end, 37 cases of routine treatment group and 40 cases of KD treatment group were included in the study. All children in both groups received comprehensive rehabilitation training. On this basis, the KD treatment group was given a modified Atkins regimen of ketogenic diet. Before and after treatment, 69 months were given to both groups. Gesell development scale was used in children. Chinese Young Children's emotional and Social Development scale CITSEAA / Achenbach Child behavior scale (CBCLA) and Infant Junior Middle School students' Social Life ability scale (S-M) were used to compare the neurobehavioral development between the two groups. Results the Gesell scores of the two groups were compared in adaptability, fine motion, and fine movement after treatment for 6 months and 9 months after treatment. The improvement of KD treatment group was better than that of routine treatment group, the CITSEA/CBCL score of KD treatment group was better than that of routine treatment group, and the improvement of KD treatment group was better than that of routine treatment group at 9 months after treatment, and 9 months after treatment, the improvement of KD treatment group was better than that of routine treatment group, and 9 months after treatment, the improvement of KD treatment group was better than that of routine treatment group. The improvement of score was better than that of routine treatment group (P 0.05). KD could improve the neurobehavioral development, emotion and social behavior of children with GDD. And the adverse reaction was less.
【作者单位】：郑州大学第三附属医院儿童康复科/河南省小儿脑损伤重点实验室/郑州市儿童脑瘫防治重点实验室;
【分类号】：R749.94

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