布地奈德联合不同药物雾化吸入治疗儿童哮喘疗效比较

发布时间：2018-03-18 22:09

本文选题：儿童哮喘　切入点：布地奈德　出处：《中国医院药学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:比较布地奈德联合特布他林,布地奈德联合特布他林及异丙托溴铵雾化吸入治疗儿童哮喘的临床疗效。方法:将某院急性发作期中度哮喘患儿74例,随机分为对照组和治疗组。在吸氧、止咳祛痰等常规治疗基础上,对照组给予布地奈德联合特布他林雾化吸入,治疗组在以上治疗的基础上加用异丙托溴铵雾化吸入。按体质量给予不同剂量药物,7 d为1疗程。分析比较2组患儿的临床疗效、临床症状消失时间、肺功能及实验室指标的变化。结果:治疗组患儿的总有效率明显高于对照组,治疗组的临床症状消失时间和住院时间明显比对照组短,2组患儿在总有效率、临床症状消失时间和住院时间上差异存在显著性(P0.05);治疗后,2组患儿的肺通气功能指标均有明显上升,治疗组患儿的肺通气功能指标显著高于对照组,组间差异有统计学意义(P0.05);治疗后,除大于20 kg患儿的EOS%指标外,治疗组患儿的其他实验室指标均明显低于对照组(P0.05)。结论:雾化吸入布地奈德联合特布他林及异丙托溴铵的疗效优于布地奈德联合特布他林,症状消失时间缩短、肺功能明显改善并能够减少不良反应是治疗儿童哮喘的有效选择。
[Abstract]:Objective: to compare the clinical efficacy of budesonide combined with terbutaline, budesonide combined with terbutaline and ipratropium bromide in the treatment of childhood asthma. The control group was randomly divided into control group and treatment group. The control group was given budesonide combined with terbutaline aerosol inhalation on the basis of routine treatment such as oxygen inhalation, cough and expectoration, etc. The treatment group was treated with ipratropium bromide atomization inhalation on the basis of the above treatment and was given different doses of drugs for 7 days as a course of treatment according to body mass. The clinical efficacy and the time of disappearance of clinical symptoms were analyzed and compared between the two groups. Results: the total effective rate in the treatment group was significantly higher than that in the control group, and the clinical symptom disappearance time and hospitalization time in the treatment group were significantly shorter than those in the control group, and the total effective rate in the treatment group was significantly shorter than that in the control group. There was significant difference in the time of disappearance of clinical symptoms and hospitalization time between the two groups, and the pulmonary ventilation function index of the two groups increased significantly after treatment, and the pulmonary ventilation function index of the treatment group was significantly higher than that of the control group, and that of the two groups was significantly higher than that of the control group. The difference between groups was statistically significant (P 0.05), except for the EOS% index of more than 20 kg children after treatment, Conclusion: the efficacy of inhaled budesonide combined with terbutaline and ipratropium bromide is better than that of budesonide combined with terbutaline, and the time of symptom disappearance is shorter than that of budesonide combined with terbutaline. The improvement of pulmonary function and the reduction of adverse reactions are the effective choice in the treatment of asthma in children.
【作者单位】：青岛大学药学院药理教研室;临沂市妇女儿童医院;山东医学高等专科学校;
【分类号】：R725.6

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