住院新生儿临床分离病原菌及其耐药性分析

发布时间：2018-03-23 09:14

本文选题：病原菌　切入点：药敏分析　出处：《实用医学杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的分析住院新生儿临床分离病原菌的分布特点及药敏结果,为临床合理选择抗菌素提供参考。方法以新生儿临床标本中分离出病原菌为研究对象,分析病原菌的分布及耐药特点。15 796份标本按操作规范培养分离,经全自动细菌鉴定系统VITEK-2 compact进行鉴定及药敏试验,应用WHONET5.4软件分析药敏结果。结果共分离病原菌1 125株,阳性率为7.1%,G-菌742株,占66.0%;G+菌355株,占31.6%,肺炎克雷伯菌和金黄色葡萄球菌分别占G-菌和G+菌的首位。G-菌对氨苄西林、一/二代头孢等耐药率较高,肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌对亚胺培南的抵抗率24.0%。葡萄球菌中的MRSA和MRSCN的检出率分别是35.7%、73.3%,对青霉素、头孢类、红霉素等不同程度耐药,对万古霉素、替加环素等100%敏感。结论住院新生儿临床分离的病原菌以G-杆菌和葡萄球菌为主,耐药性较为严重。
[Abstract]:Objective to analyze the distribution characteristics and drug sensitivity of pathogenic bacteria in clinical isolation of hospitalized neonates, and to provide a reference for the rational selection of antibiotics. Methods the pathogenic bacteria isolated from clinical specimens of newborns were taken as the research objects. The distribution and drug resistance characteristics of pathogenic bacteria were analyzed. 15 796 samples were cultured according to the standard of operation. The results of identification and susceptibility tests were carried out by automatic bacterial identification system VITEK-2 compact, and the results of drug sensitivity were analyzed by WHONET5.4 software. Results 1 125 strains of pathogenic bacteria were isolated. The positive rate was 7.42 strains of G- bacteria, which accounted for 66.0G, and occupied 31.660.The resistance rates of Klebsiella pneumoniae and Staphylococcus aureus to ampicillin and cephalosporin were higher than those of Staphylococcus aureus and Klebsiella pneumoniae, respectively, and the resistance rate of Klebsiella pneumoniae to ampicillin and the first / second generation of cephalosporins was higher than that of Staphylococcus aureus. The resistance rate of Pseudomonas aeruginosa and Acinetobacter baumannii to imipenem was 24.0.The detectable rate of MRSA and MRSCN in Staphylococcus was 35.73.3cm, resistant to penicillin, cephalosporins, erythromycin and vancomycin, respectively. Conclusion the main pathogens isolated from hospitalized neonates are G- bacilli and Staphylococcus, and the drug resistance is more serious.
【作者单位】：广东省妇幼保健院医院感染管理科;
【基金】：广东省医学科学技术研究基金项目(编号:B2015136)
【分类号】：R446.5;R722.1

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