氟西汀联合多塞平治疗儿童抑郁症疗效及安全性观察

发布时间：2018-03-25 04:06

本文选题：抑郁症　切入点：儿童　出处：《山东医药》2017年20期

【摘要】：目的探讨氟西汀联合多塞平治疗儿童抑郁症的疗效及安全性。方法将100例抑郁症儿童(8~14岁)随机均分为观察组和对照组,每组50例。两组均给予多塞平治疗,观察组再给予氟西汀治疗,疗程均为6周。两组分别于治疗前及治疗2、4、6周时进行汉密尔顿抑郁量表(HAMD)及汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)评分,治疗6周评价疗效及不良反应。结果两组治疗2、4、6周HAMD、HAMA评分均逐渐降低,观察组降低幅度更大(P均0.05)。两组治疗2、4、6周时TESS评分比较差异均无统计学意义(P均0.05)。观察组治疗总有效率为92.00%,高于对照组的76.00%(P0.05)。观察组治疗期间不良反应发生率为36.00%,对照组为26.00%,两组比较P0.05;对照组嗜睡发生率高于观察组,观察组失眠和皮疹发生率高于对照组(P均0.05)。结论多赛平联合氟西汀可提高抑郁症儿童的治疗效果,但联合用药可能增加患儿皮疹、失眠的发生率。
[Abstract]:Objective to investigate the efficacy and safety of fluoxetine combined with doxepin in the treatment of depression in children. Methods 100 children with depression aged 814 years were randomly divided into observation group and control group with 50 cases in each group. The observation group was treated with fluoxetine for 6 weeks. The two groups were evaluated with Hamilton Depression scale (Hamd), Hamilton anxiety scale (Hamilton anxiety scale) and side effects scale (TESS) before and after 2 weeks of treatment. Results the score of HAMD-Hama in the two groups decreased gradually at 6 weeks after treatment. There was no significant difference in TESS scores between the two groups at 6 weeks after treatment. The total effective rate of treatment in the observation group was 92.00, which was higher than that in the control group (76.00 and P 0.05). The incidence of adverse reactions in the observation group was 36.00. The incidence of somnolence in the control group was higher than that in the observation group. Conclusion doxepin combined with fluoxetine can improve the therapeutic effect of depression in children with depression, but combined therapy may increase the incidence of rash and insomnia in children.
【作者单位】：广州市妇女儿童医疗中心;
【分类号】：R749.4

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