149例婴儿肝炎综合征的临床分析

发布时间：2018-04-01 12:00

本文选题：婴儿肝炎　切入点：综合征　出处：《吉林大学》2012年硕士论文

【摘要】：婴儿肝炎综合征（infantile hepatitis syndrome，IHS）简称婴肝征，是指一岁以内的婴儿（包括新生儿）出现黄疸、肝脏肿大和肝功能异常的一组临床综合征。其病因复杂，合并症和并发症多，愈后情况各不相同，严重者可出现肝硬化、肝昏迷、肝肾综合征，甚至死亡。本研究选取吉林大学第一医院儿内四科2008年1月~2012年5月期间入院的确诊为婴儿肝炎综合征的患者149例为研究对象进行临床分析。目的：探讨婴儿肝炎综合征的主要病因及其影响因素；对IHS的临床特征、并发症、诊断措施及疗效评价进行统计分析，总结IHS行之有效的诊断方法及治疗方式；归纳IHS的临床诊断思路，更好地协助临床早期诊断和治疗。方法：选取吉林大学第一医院儿内四科2008年1月~2012年5月期间入院的确诊为婴儿肝炎综合征的患者149例。采用回顾性分析的研究方法，，根据研究内容，设计调查表，从病历中提取相关信息。记录患者年龄、性别、入院诊断、出院情况、症状和体征、实验室检查结果等信息，并进行相应的统计学分析。结果：①本组患者的年龄为0~12个月不等（平均为2个月），主要集中在2个月以上，占57.72%；男性患者多于女性，男女比例为1.61：1；②多数患儿都因黄疸不退或退而复现首诊；③入院时基本状况：149例婴儿肝炎综合征的患者中61例合并呼吸道感染，占40.94%；17例合并消化系统感染，占11.41%；7例合并心血管畸形，占4.69%；11例患儿存在心肌酶学改变，占7.38%；巨细胞病毒抗体阳性者67例，占44.97%。149例均有不同程度肝功能损伤。结论：（1）IHS患儿发病年龄多在1~12个月之间主要集中在2个月以上，占57.72%；（2）男性HIS患者多于女性，男女比例为1.61：1；（3）黄疸是IHS最主要的首发症状；（4）IHS患者可伴有呼吸系统感染，消化系统感染、心血管畸形等症状。（5）巨细胞病毒（CMV）肝炎在婴儿肝炎综合征中居首位。（6）IHS患儿可存在心肌酶改变的情况。（7）治疗后肝功能较治疗前有明显好转。
[Abstract]:Infantile hepatitis syndrome refers to a group of clinical syndromes with jaundice, hepatomegaly and abnormal liver function in infants (including newborns) under one year of age. In severe cases, liver cirrhosis, liver coma, hepatorenal syndrome, From January 2008 to May 2012 149 patients with infantile hepatitis syndrome (infantile hepatitis syndrome) admitted in the first Hospital of Jilin University were selected for clinical analysis. Objective: to investigate the main etiology and influencing factors of infantile hepatitis syndrome, to analyze the clinical features, complications, diagnostic measures and evaluation of curative effect of IHS, and to summarize the effective diagnostic methods and treatment methods of IHS. Summarize the clinical diagnosis ideas of IHS, and better assist in early clinical diagnosis and treatment. Methods: 149 cases of infantile hepatitis syndrome from January 2008 to May 2012 in the first Hospital of Jilin University were selected. The patient's age, sex, admission diagnosis, discharge status, symptoms and signs, results of laboratory examination and so on were recorded and analyzed statistically. Results the age of the patients ranged from 0 to 12 months (mean 2 months), mainly in more than 2 months (57.72%). The ratio of male and female was 161: 1 / 2. Most of the children were diagnosed with the basic condition at admission of 3: 149 cases of infantile hepatitis syndrome, of which 61 cases were complicated with respiratory tract infection, 17 cases were complicated with digestive system infection, and 7 cases were complicated with cardiovascular malformation because of their jaundice. There were 11 cases of myocardial enzyme changes (7.38%) and 67 cases of cytomegalovirus antibody positive (44.97.149 cases) with liver function injury. Conclusion the most common onset age of children with HIS is 1 ~ 12 months, accounting for 57.72%) male patients with HIS are more than female, the ratio of male and female is 1.61: 1 / 3) jaundice is the most important initial symptom of IHS. Symptoms of digestive system infection, cardiovascular malformation, etc. (CMV) hepatitis was the most important in infantile hepatitis syndrome. The changes of myocardial enzymes in children with IHS were significantly improved after treatment.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.7

【相似文献】