丙酸倍氯米松雾化治疗毛细支气管炎的疗效研究

发布时间：2018-04-03 19:49

本文选题：毛细支气管炎　切入点：倍氯米松　出处：《中国全科医学》2017年35期

【摘要】：目的探讨丙酸倍氯米松雾化治疗毛细支气管炎患儿的疗效及安全性。方法选取2014年12月—2015年3月河北省儿童医院呼吸一科、河北医科大学第三医院儿科收治的毛细支气管炎患儿150例,将患儿按照随机分组表先后顺序分为对照组(n=70)和试验组(n=80)。对照组给予0.9%氯化钠溶液1 ml+复方异丙托溴铵1.25ml,试验组给予丙酸倍氯米松0.4 mg(1 ml)+复方异丙托溴铵1.25 ml,两组均雾化治疗2次/d,连用5 d。记录两组住院时、6 h、12 h、24 h、48 h、72 h、96 h临床病情严重程度评分;治疗前及治疗5 d后达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、呼出气一氧化氮(FeNO)水平。并观察两组不良反应发生情况。结果治疗方法与时间对临床病情严重程度评分存在交互作用(F_(交互)=7.983,P0.001),且二者对临床病情严重程度评分的主效应显著(F_(组间)=26.929,P0.001;F_(时间)=553.770,P0.001)。治疗后,试验组TPTEF/TE、VPEF/VE高于对照组,Fe NO低于对照组(P0.05)。对照组治疗后TPTEF/TE、Fe NO高于治疗前,试验组治疗后TPTEF/TE、VPEF/VE、Fe NO均高于治疗前(P0.05)。治疗过程中两组均无咳嗽、气管痉挛、咽喉部不适、肌肉震颤、鹅口疮、声音嘶哑等不良反应发生。结论对毛细支气管炎患儿在常规治疗的基础上加用丙酸倍氯米松可更快地缓解患儿急性发作症状,改善小气管功能,无激素相关的不良反应发生。
[Abstract]:Objective to evaluate the efficacy and safety of beclomethasone propionate in the treatment of bronchiolitis.The control group was given 1 ml of compound ipratropium bromide in 0.9% sodium chloride solution, and the experimental group was given beclomethasone propionate 0.4 mg(1 / ml). The two groups were treated by atomization twice a day for 5 days.Adverse reactions were observed in both groups.After treatment, TPTEF / TEV PEF / VE in the experimental group was higher than that in the control group, and the level of FeNO in the control group was lower than that in the control group (P 0.05).After treatment, TPTEF / TEF- Fe no in the control group was higher than that before treatment, and TPTEF / TEVPEF- VEFeNO was higher in the experimental group after treatment than that before treatment (P 0.05).There were no adverse reactions such as cough, tracheospasm, pharynx discomfort, muscle tremor, thrush, hoarseness and so on.Conclusion adding beclomethasone propionate to children with bronchiolitis on the basis of routine treatment can relieve the symptoms of acute attack and improve the function of small trachea more quickly without the occurrence of steroid related adverse reactions.
【作者单位】：河北省儿童医院;河北医科大学第三医院;
【基金】：河北省科技支撑计划项目(112761132)
【分类号】：R725.6

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