大鼠获得性漏斗胸形成过程中肺功能的观察

发布时间：2018-04-08 17:43

  本文选题：获得性漏斗胸　切入点：肺功能　出处：《大理学院》2012年硕士论文

【摘要】：目的：通过幼鼠实验观察获得性漏斗胸形成过程中肺功能的变化。 方法：4周龄SD大鼠40只，分为实验组和对照组各20只。实验组行经胸骨旁切断下为三对肋软骨观察漏斗胸形成，（1）于术后3天和4周测定动物肺功能指标各10只并与对照组同龄大鼠对照。（2）于术后3天测定动物血气分析指标各8只并与对照组同龄大鼠对照，于术后4周测定血气分析指标6只与3只对照组同龄大鼠对照。检测结果均进行t检验分析。 结果：漏斗胸造模术后一周内动物呼吸状况变化明显，在其后的饲养过程中，动物漏斗胸逐渐形成，存活状态与正常动物并无明显差别。Ri在术后3d和4w的检测结果在同龄动物组间比较差异均有显著性，造模术后动物的吸气阻力增加（P0.05）；Re、Cl、Fev0.2和FVC等指标在术后3d的测得值组间差异有显著性，Re在实验组增加外其他3个指标减小（P0.05），FVC在8周时组间比较P=0.05，说明该指标在造模术后发生了改变，而MVV、Fev0.2FVC、PEF25-75%和PEF等指标不论在术后3d还是4w的检测结果组间比较差异均无统计学意义（P0.05）。PH，PCO_2，，ctHb，pO_2（A-a）术后3天的检测结果在同龄动物组间比较差异均有显著性，但是术后4周的检测结果在同龄动物组间比较差异无显著性。PO_2,SO_2,HCO_3ˉ术后3天和4周的检测结果在同龄动物组间比较差异均无显著性。 结论：漏斗胸造模术后近期胸壁和肺的顺应性均降低，吸气和呼气阻力增加，肺泡通气量和肺泡摄取氧含量均降低，随着漏斗胸的形成和稳定，动物肺功能又重新建立适应，肺泡通气量和肺泡摄取氧含量均恢复至正常，但胸廓的顺应性仍较正常降低。
[Abstract]:Objective: to observe the changes of pulmonary function during the formation of acquired funnel chest in young rats.Methods 40 Sprague-Dawley rats aged 4 weeks were divided into experimental group and control group.There were 8 rats in each group and control group in the same age group.The indexes of blood gas analysis were measured 4 weeks after operation in 6 rats and 3 control groups.The test results were analyzed by t-test.Results: the respiratory status of the animals changed significantly within one week after the operation of the funnel chest model. During the later feeding process, the funnel chest gradually formed.There was no significant difference between the survival state and the normal animals. The results of Ri on the 3rd day and the 4th week after operation were significantly different between the same age groups.However, there was no significant difference in the results between the same age groups 4 weeks after operation. There was no significant difference in the results between the same age groups 3 days and 4 weeks after operation.Both alveolar ventilation volume and alveolar oxygen content returned to normal, but thoracic compliance was still lower than normal.
【学位授予单位】：大理学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R726.5

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