基于数据挖掘防治小儿反复呼吸道感染方药配伍规律研究

发布时间：2018-04-19 05:42

本文选题：小儿 + 反复呼吸道感染　；参考：《重庆医学》2017年35期

【摘要】：目的探讨小儿反复呼吸道感染中药内服复方配伍规律。方法检索收集中国生物医学文献数据库、知网、维普、万方4个数据库中防治小儿反复呼吸道感染的中药内服复方文献,检索时间为2006年1月至2016年7月,将文献整理得到符合要求的中药内服复方进行术语规范化等处理,抽取信息,建立Excel表,应用开源软件包R i386 3.3.0对数据进行频数、关联规则分析及聚类分析。结果筛选出311首方,208味中药进行分析,发现配伍频数较高的中药为白术、甘草、防风、黄芪、太子参、茯苓、陈皮等;强关联规则提示以黄芪、白术、防风等核心药物组成的玉屏风散加减为防治小儿反复呼吸道感染的基本方;聚类分析结果发现黄芪-龙骨-牡蛎、白术-茯苓-甘草-黄芪-党参等中药配伍。结论通过对药物频数、强关联规则、药物聚类的分析,可以揭示小儿反复呼吸道感染防治组方的配伍规律,为临床优化处方、提高疗效提供参考依据。
[Abstract]:Objective to explore the law of compound prescription of traditional Chinese medicine for repeated respiratory tract infection in children.Methods four databases of Chinese biomedical literature database, Zhiwang, Weipu and Wanfang were searched and collected for the prevention and treatment of recurrent respiratory tract infection in children. The retrieval time was from January 2006 to July 2016.In this paper, the documents are sorted out to get the Chinese herbal medicine compound which meets the requirements, and the terminology is standardized, the information is extracted, the Excel table is established, and the frequency, association rule analysis and clustering analysis of the data are carried out by using the open source software package Ri386 3.3.0.Results 311 Chinese medicines with high compatibility frequency were selected and analyzed. The results showed that the Chinese medicines with high compatibility frequency were Atractylodes macrocephala, Radix Glycyrrhiza, Fangfeng, Astragalus, Radix Pseudostellariae, Poria cocos, Chen Pei, etc. The strong association rules indicated that Astragalus, Atractylodes macrocephala,Yupingfeng powder composed of Fangfeng and other core drugs was added and subtracted as the basic prescription for prevention and treatment of recurrent respiratory tract infection in children. The results of cluster analysis showed that Astragalus membranaceus-keel-oyster, Atractylodes macrocephala-Poria cocos-Glycyrrhiza-Radix Codonopsis and so on were compatible.Conclusion the analysis of drug frequency, strong association rule and drug clustering can reveal the compatibility of the prescription for prevention and treatment of recurrent respiratory tract infection in children, and provide a reference for clinical optimization of prescription and improvement of curative effect.
【作者单位】：广西中医药大学研究生学院;广西中医药大学第一附属医院儿科;湖南中医药大学中医诊断学科;湖南省人民医院麻醉科;广西中医药大学壮医学院;
【基金】：广西高校壮医方药基础与应用研究重点实验室科学研究课题项目(桂教科研[2016]6号zyfy201605) 湖南中医药大学中医诊断重点学科开放基金(2015ZYZD01) 湖南中医药大学第一附属医院国家中医临床研究基地中医药防治重症肝炎临床防治中心开放基金项目(ZZ-GY05)
【分类号】：R272;TP311.13

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