本溪2012—2015年手足口病流行病学及病原学特征分析

发布时间：2018-04-26 06:14

本文选题：手足口病 + 流行病学　；参考：《中国公共卫生》2017年02期

【摘要】：目的了解辽宁省本溪市手足口病流行现状及病原学特征,及时掌握手足口病流行规律和趋势。方法对2012—2015年本溪市手足口病资料进行分析,采用逆转录PCR方法进行病毒核酸检测。结果 2012—2015年本溪市共报告手足口病病例2 276例,年均发病率为33.23/10万,无重症和死亡病例。病例高发期在6-9月份;发病年龄主要为1~5岁,病例以托幼儿童和散居儿童为主,男性高于女性。2012—2015年共检测1 105例手足口病标本,检出阳性标本659例,阳性检出率为59.64%。阳性标本中,CoxA16型、EV71型、CoxA16型和EV71型混合感染及其他肠道病毒的构成比分别为28.83%、21.40%、2.73%和47.04%,病原构成呈动态变化。结论2012—2015年本溪市手足口病发病存在明显的时间、地区、年龄、性别和职业差异,发生的手足口病主要由CoxA16和EV71型病毒引起,是EV71型和CoxA16型为主混合型感染地区,目前逐渐向以其他肠道病毒为主混合型感染地区转变。
[Abstract]:Objective to understand the epidemic status and etiological characteristics of hand, foot and mouth disease (HFMD) in Benxi City, Liaoning Province, and to grasp the epidemic law and trend of HFMD in time. Methods the data of hand, foot and mouth disease from 2012 to 2015 in Benxi City were analyzed and the viral nucleic acid was detected by reverse transcription PCR. Results from 2012 to 2015, 2 276 cases of hand, foot and mouth disease were reported in Benxi City. The average annual incidence rate was 33.23 / 100 000. There were no severe or fatal cases. The period of high incidence was from June to September, the age of onset was mainly 1 to 5 years old, and the cases were mainly kindergarten children and scattered children. A total of 1 105 hand-foot-mouth disease samples were detected in males and females in 2012-2015. 659 positive specimens were detected, and the positive rate was 59.64%. In the positive specimens, the compositional ratios of co-infection of CoxA16 and EV71 and other enterovirus were 28.83% and 47.04%, respectively. Conclusion HFMD in Benxi City from 2012 to 2015 has obvious time, region, age, sex and occupation difference. HFMD is mainly caused by CoxA16 and EV71 virus, which is a mixed infection area of EV71 type and CoxA16 type. At present, there is a gradual transition to other enterovirus-dominated mixed infection areas.
【作者单位】：本溪市疾病预防控制中心传染病与感染性疾病控制科;
【分类号】：R725.1;R181.3

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