桥本氏甲状腺炎伴Hp感染患儿血清IL-17与APN水平及TLR蛋白表达的影响

发布时间：2018-05-02 04:38

  本文选题：桥本氏甲状腺炎伴Hp感染 + 血清　； 参考：《中华医院感染学杂志》2017年19期

【摘要】：目的研究与观察桥本氏甲状腺炎伴幽门螺杆菌(Hp)感染患儿的血清白细胞介素17(IL-17)、脂联素(APN)水平及Toll样受体(TLR)蛋白表达变化情况。方法选取2013年2月-2016年10月医院收治的69例桥本氏甲状腺炎伴Hp感染患儿为A组,69例桥本氏甲状腺炎患儿为B组,69例Hp感染患儿为C组,69名健康儿童为D组,将四组血清IL-17、APN水平及TLR蛋白指标进行比较,同时比较A、B组中不同桥本氏甲状腺炎分期患儿,A、C组中不同Hp分型患儿的上述指标检测结果。结果 A组的血清IL-17、APN水平及TLR蛋白指标(TLR2及TLR9)分别为(10.25±1.34)ng/L、(11.15±1.36)mg/L、(5.86±0.64)ng/ml及(19.84±2.68)ng/ml,均高于B组(7.91±0.95)ng/L、(8.90±0.93)mg/L、(3.91±0.34)ng/ml、(11.02±1.93)ng/ml,C组的(7.80±0.93)ng/L、(8.87±0.90)mg/L、(3.78±0.31)ng/ml、(10.84±1.89)ng/ml及D组的(5.76±0.45)ng/L、(6.95±0.73)mg/L、(2.02±0.23)ng/ml、(5.56±0.60)ng/ml,B组及C组均高于D组,且A、B两组中不同桥本氏甲状腺炎分期患儿的血清IL-17、APN水平及TLR蛋白指标表达水平存在显著性差异,A、C两组中不同Hp分型患儿的上述指标检测结果也存在显著性差异(P均0.05)。结论桥本氏甲状腺炎伴Hp感染患儿的血清IL-17、APN水平及TLR蛋白指标表达呈现明显异常状态,且桥本氏甲状腺炎分期与Hp分型均对其表达有较大的影响,应重视对上述指标的监测与改善。
[Abstract]:Objective to study the changes of serum interleukin-17 (IL-17) and adiponectin (APN) levels and the expression of Toll like receptor (TLR) protein in children with Hashimoto's thyroiditis complicated with Helicobacter pylori (HP) infection. Methods 69 cases of Hashimoto's thyroiditis with HP infection were selected from February 2013 to October 2016. 69 cases of Hashimoto's thyroiditis were selected as group A and 69 cases of HP infection in group B and 69 healthy children in group C as group D. The serum IL-17 APN levels and TLR protein levels were compared among the four groups, and the results were compared among the patients with different Hashimoto's thyroiditis stages and different HP typing in group A (P < 0.05). 缁撴灉 A缁勭殑琛，

本文编号：1832393