喜炎平注射液治疗小儿上呼吸道感染疗效和安全性的系统评价

发布时间：2018-05-12 00:33

本文选题：喜炎平 + 利巴韦林　；参考：《中药药理与临床》2017年03期

【摘要】：目的:探讨喜炎平注射液和利巴韦林注射液治疗小儿上呼吸道感染的临床疗效及安全性。方法:计算机检索Pub Med、EMbase、The Cochrane Library、相关期刊论文(CNKI)、中国生物医学文献数据库(CBM)、万方数据库(Wan Fang Data)和维普中文科技期刊全文数据库(VIP),关于喜炎平注射液和利巴韦林注射液比较治疗小儿上呼吸道感染的随机对照试验(RCTs),检索时限均从建库至2017年1月22日。由两位研究员按纳入和排除标准严格筛选文献、进行质量评价、提取数据后采用Rev Man5.3软件进行Meta分析。结果:最终纳入10个研究,共1486名患者。Meta分析结果显示,喜炎平注射液治疗的总有效率显著高于利巴韦林注射液,在退热时间、咳嗽缓解时间、咽痛缓解时间、鼻塞流涕消失时间等方面有明显优势。两组在不良反应恶心呕吐发生率上的差异没有统计学意义。结论:喜炎平注射液治疗小儿上呼吸道感染在主要临床症状改善方面明显优于利巴韦林注射液,安全性的分析需要大样本量的随机试验加以验证。
[Abstract]:Objective: to investigate the efficacy and safety of Xiyanping injection and ribavirin injection in the treatment of upper respiratory tract infection in children. Methods: the Pub Medbase, the Cochrane Library, the Chinese Journal Full-text Database, the Chinese Biomedical Literature Database, the Wanfang Database, the Wan Fang data, and the Weipu full text Database of Chinese Sci-tech Journals were searched on Pub Medbase, the Chinese Journal of Science and Technology, and the full text database of Xiyanping injection and ribavirin. A randomized controlled trial for the treatment of upper respiratory tract infection in children with injection was conducted. The search time of RCTs was from the establishment of the bank to January 22, 2017. According to the inclusion and exclusion criteria, two researchers strictly sifted the literature, evaluated the quality, extracted the data and used Rev Man5.3 software for Meta analysis. Results: the total effective rate of Xiyanping injection was significantly higher than that of ribavirin injection, and the total effective rate of Xiyanping injection was significantly higher than that of ribavirin injection, including antipyretic time, cough relief time and pharyngeal pain relief time. There are obvious advantages in the time of disappearance of nasal congestion. There was no significant difference in the incidence of nausea and vomiting between the two groups. Conclusion: Xiyanping injection is superior to ribavirin injection in improving the main clinical symptoms of children with upper respiratory tract infection.
【作者单位】：暨南大学药学院;
【分类号】：R272

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