中医药治疗小儿咳嗽变异性哮喘疗效及安全性的Meta分析

发布时间：2018-05-20 22:34

本文选题：小儿咳嗽变异性哮喘 + 中医药　；参考：《辽宁中医药大学》2012年硕士论文

【摘要】：研究目的：本文系统评价以中医药为主治疗小儿咳嗽变异性哮喘的疗效及安全性。研究方法：通过检索2001～2011年发表在国内各大期刊关于中医药治疗小儿咳嗽变异性哮喘的随机对照临床研究文献，采用Meta分析等方法统计相关数据，对中医药治疗小儿咳嗽变异性哮喘的疗效以及用药的安全性进行系统的评价。结果：通过对国内的各大期刊的文献检索后，共检索出相关文献约302篇。其中仅有43篇满足本研究的纳入标准，应用修改后的Jadad质量评价表评定纳入研究的文献质量普遍偏低。Meta分析结果显示两组在临床总有效率、安全性以及复发率方面差异有统计学意义，在改善患儿肺功能方面无显著性差异。结论：通过对已发表的关于中医药治疗小儿咳嗽变异性哮喘的文献进行Meta分析，初步证实中医药治疗小儿咳嗽变异性哮喘的有效性及安全性。但因纳入的文献缺乏高质量的研究，所以现有的评价结果不能得出肯定的结论，故对本评价的结果应谨慎对待。尚需遵循“多中心，大样本，前瞻性，，随机对照，双盲”科研原则，设计实施良好的临床随机对照试验，提高试验的质量，为临床研究提供指导及充足的证据。
[Abstract]:Research purposes: This article systematically evaluated the efficacy and safety of Chinese medicine in the treatment of infantile cough variant asthma.
Methods: a randomized controlled clinical study published on Chinese medicine for 2001~2011 years to treat children with cough variant asthma was published in 2001~2011 years. The relevant data were statistically analyzed by using the method of analysis and so on. The efficacy of Chinese medicine in treating children with cough variant asthma and the safety of drug use were systematically evaluated.
Results: About 302 articles were retrieved through the literature retrieval of the major journals in China. Only 43 of them met the inclusion criteria of this study, and the revised Jadad quality assessment table was used to assess the general low quality of the literature included in the study. The results of the.Meta analysis showed that the two groups were in the total clinical efficiency, safety and recurrence rate. The difference was statistically significant, and there was no significant difference in improving lung function in children.
Conclusion: through the Meta analysis of the published literature on the treatment of cough variant asthma in children with Chinese medicine, the effectiveness and safety of Chinese medicine in treating children with cough variant asthma are preliminarily confirmed. However, due to the lack of high quality research in the literature, the existing evaluation results can not reach a positive conclusion. The results should be treated carefully. The principle of "multi center, large sample, prospective, randomized controlled, double blind" scientific research should be followed, and a good clinical randomized controlled trial is designed and implemented to improve the quality of the test and provide guidance and sufficient evidence for clinical research.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R272

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