早产儿真菌血症临床特点

发布时间：2018-05-26 18:23

本文选题：婴儿 + 早产　；参考：《中国感染控制杂志》2017年09期

【摘要】：目的了解早产儿真菌血症患儿临床特点。方法回顾性分析2011年1月—2015年12月某儿童医院重症监护病房早产儿真菌血症的临床特点,比较早产儿的一般情况、实验室相关指标及药敏结果。结果 2011年1月—2015年12月该院收治确诊的真菌血症早产儿42例,其中白假丝酵母菌22例(占52.38%),近平滑假丝酵母菌13例(占30.95%),克柔假丝酵母菌3例,其他4例。按感染的主要病原菌进行分组,分为近平滑假丝酵母菌组和白假丝酵母菌组。白假丝酵母菌组母亲泌尿生殖系感染率、真菌性脑膜炎的发生率均为27.27%,高于近平滑假丝酵母菌组(分别为7.69%、0.00%),白假丝酵母菌组经外周静脉置入中心静脉导管(PICC)置管率低于近平滑假丝酵母菌组(22.73%vs 69.23%),近平滑假丝酵母菌组血小板计数低于白假丝酵母菌组,差异均有统计学意义(均P0.05)。结论早产儿真菌血症感染病原菌以近平滑假丝酵母菌和白假丝酵母菌为主,母亲孕期生殖系感染易导致白假丝酵母菌血症的发生,白假丝酵母菌血症早产儿更易患真菌性脑膜炎;PICC置管更易导致近平滑假丝酵母菌血症的发生,血小板的下降更明显。
[Abstract]:Objective to investigate the clinical characteristics of mycemia in premature infants. Methods the clinical features of mycemia of premature infants in intensive care unit of a children's hospital from January 2011 to December 2015 were analyzed retrospectively. The general situation, laboratory indexes and drug sensitivity of premature infants were compared. Results from January 2011 to December 2015, 42 cases of mycemia were diagnosed in our hospital, including 22 cases (52.38%) of Candida albicans, 13 cases (30.955%) of mycelia, 3 cases of Candida cerevisiae and 4 cases of others. According to the main pathogens of infection, they were divided into two groups: near smooth Candida cerevisiae group and Candida albicans group. Infection rate of genitourinary system in mothers of Candida albicans group, The incidence of fungal meningitis was 27.27%, which was higher than that in the near smooth Candida cerevisiae group (7.69%, respectively). The rate of PICCCimplantation in the white candida group was lower than that in the near smooth Candida cerevisiae group (22.73 vs 69.23%). The platelet count in the yeast group was lower than that in the Candida albicans group. The difference was statistically significant (P 0.05). Conclusion the pathogens of mycemia infection in premature infants are mycelia near smooth and Candida albicans. The infection of reproductive system during pregnancy may lead to the occurrence of Candida albicans. Preterm infants with mycelia were more likely to suffer from fungal meningitis and PICC catheterization was more likely to lead to the occurrence of near smooth Candida cerevisiaemia and the decrease of platelet was more obvious.
【作者单位】：湖南省儿童医院;
【分类号】：R722.6

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