早产儿出生时维生素D水平及影响因素分析

发布时间：2018-06-28 09:17

  本文选题：-羟基维生素D + 维生素D缺乏　； 参考：《中国当代儿科杂志》2017年07期

【摘要】：目的分析早产儿出生时维生素D水平及其可能影响因素。方法采集600例早产儿出生24 h内静脉血,检测血清25-羟基维生素D[25(OH)D]水平,并分析早产儿性别、出生体重、出生季节、胎龄,以及母亲的年龄、职业、早孕期体重指数(BMI)、分娩方式及妊娠期并发症等对血清25(OH)D水平的影响。结果早产儿维生素D缺乏、不足、充足的比例分别为42.0%、38.7%和19.3%。夏、秋季出生的早产儿血清25(OH)D水平显著高于冬季(P0.05),维生素D缺乏的发生率显著低于春、冬季(P0.003)。与母亲年龄≥30岁者比较,年龄30岁母亲所生早产儿血清25(OH)D水平显著降低(P0.05),维生素D缺乏的发生率显著增高(P0.017)。与母亲肥胖者比较,超重或体重正常母亲所生早产儿血清25(OH)D水平显著增高(P0.05),维生素D缺乏的发生率显著降低(P0.006)。母亲妊娠合并子vN前期者,其早产儿血清25(OH)D水平显著低于无子vN前期者(P0.05),维生素D缺乏的发生率显著高于无子vN前期者(P0.017)。多因素分析结果显示,冬春季出生、母亲年龄30岁及早孕期BMI≥28 kg/m2为早产儿维生素D缺乏的危险因素(P0.05)。结论早产儿维生素D缺乏发生率较高,有维生素D缺乏高危因素的早产儿生后需尽早补充维生素D。
[Abstract]:Objective to analyze the level of vitamin D at birth of premature infants and its possible influencing factors. Methods the venous blood samples were collected from 600 premature infants within 24 hours of birth. The serum levels of 25-hydroxyvitamin D [25 (OH) D] were measured, and the sex, birth weight, birth season, gestational age, age and occupation of preterm infants were analyzed. The serum 25 (OH) D level of premature infants born in summer and autumn was significantly higher than that in winter (P0.05), and the incidence of vitamin D deficiency was significantly lower than that in spring and winter (P0.003). Compared with obese mothers, the serum 25 (OH) D level of preterm infants born to overweight or normal mothers was significantly higher (P0.05), and the incidence of vitamin D deficiency was significantly lower (P0.006). The serum levels of 25 (OH) D in preterm infants were significantly lower than those without vN (P0.05), and the incidence of vitamin D deficiency was significantly higher than that in those without vN (P0.017). The results of multivariate analysis showed that birth in winter and spring and maternal age 鈮，

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