新生儿脓毒血症诊疗最新研究进展

发布时间：2018-07-04 18:35

本文选题：新生儿 + 脓毒血症　；参考：《中华医院感染学杂志》2017年24期

【摘要】：新生儿脓毒血症(neonatal sepsis,NS)是新生儿期的危重症,发病率为1~10/1000活产儿,病死率1%~70%不等,存在区域差异及不同新生儿人群特点;NS病原菌谱呈现动态变迁,目前凝固酶阴性葡萄球菌为新生儿重症监护室分离出的最常见的病原菌,非B族溶血性链球菌的病原体引发的早发型NS的发生率有所上升;NS临床特点是非特异性症状及个体化临床表现,常易被漏诊和误诊;近年来NS的检查方法和治疗措施存在的新研究进展,可以为NS的早期诊断和精确治疗提供帮助;早产儿、低出生体重儿及其母亲感染性疾病的新生儿是防治NS需关注的高危人群;NS相关的医院感染控制方法及管理策略是未来研究重点之一;多学科研究结果需在统一的诊断标准下进行整合,持续推进临床NS诊断治疗技术的进步。
[Abstract]:Neonatal sepsis NS (neonatal sepsis NS) is a critical disease in neonatal stage. The incidence rate of neonatal sepsis is 110 / 1000 live infants, the mortality rate varies from 1 to 70%. There are regional differences and the characteristics of different newborns are characterized by dynamic changes of NS pathogenic bacteria spectrum. Currently coagulase-negative staphylococcus is the most common pathogen isolated from neonatal intensive care unit. The incidence of early-onset NS caused by pathogens of non-B group hemolytic streptococcus increased. The clinical characteristics of NS were nonspecific symptoms and individualized clinical manifestations, which were often missed and misdiagnosed. In recent years, the new research progress in the examination methods and treatment measures of NS can provide help for the early diagnosis and accurate treatment of NS. Low birth weight infants and their newborns with infectious diseases of their mothers are the nosocomial infection control methods and management strategies related to NS which should be paid attention to in the prevention and treatment of NS. Multidisciplinary research results need to be integrated under the unified diagnostic criteria to continuously promote the progress of clinical NS diagnosis and treatment technology.
【作者单位】：首都医科大学附属北京妇产医院围产医学部新生儿科;复旦大学附属中山医院感染病科医院感染管理科;
【分类号】：R722.1

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