雾化吸入沙丁胺醇混悬液治疗哮喘患儿的临床研究

发布时间：2018-11-14 15:24

【摘要】：目的观察雾化吸入沙丁胺醇治疗小儿哮喘的临床疗效及对患儿肺功能、血清嗜酸性粒细胞(EOS)、免疫球蛋白E(Ig E)的影响。方法将160例患儿随机分为试验组和对照组,各80例。对照组患儿雾化吸入布地奈德混悬液1.0mg,每次5 min,每天2次;试验组在对照组治疗之前给予沙丁胺醇溶液2.5 mg,每次5 min,每天2次,雾化吸入。2组患儿均治疗2周。比较2组患儿治疗前后及治疗后3个月的肺功能变化,观察治疗前后2组EOS、Ig E水平。结果治疗后,试验组总有效率为98.68%(75/76例),对照组为84.13%(53/63例),差异有统计学意义(P0.05)。治疗后3个月,试验组和对照组用力肺活量(FVC)分别为(79.34±6.52),(70.20±3.34)L;第1秒用力通气量为(FEV1)分别为(80.12±3.32),(68.25±2.90)L;峰值呼气流速(PEF)分别为(82.08±9.62),(71.21±4.52)L·min-1;肺活量(VC)分别为(83.42±4.10),(73.17±2.34)L,差异均有统计学意义(均P0.05)。试验组和对照组外周血EOS绝对值分别为(0.52±0.13)×109/L,(0.96±0.23)×109/L;血清Ig E水平分别为(105.32±62.35),(222.58±84.71)ng·m L-1,差异均有统计学意义(均P0.05)。对照组出现恶心1例(1.59%),试验组出现声嘶2例(2.63%),2组均未出现药物过敏、院内感染、皮疹等药物不良反应,2组药物不良反应发生率差异无统计学意义(P0.05)。结论糖皮质激素联合沙丁胺醇雾化吸入对小儿哮喘的临床疗效显著,且能明显降低血液EOS和Ig E水平,改善肺功能状态。
[Abstract]:Objective to observe the clinical effect of aerosol inhalation salbutamol on children's lung function and serum eosinophil (EOS), immunoglobulin E (Ig E). Methods 160 children were randomly divided into experimental group and control group with 80 cases each. In the control group, budesonide suspension was inhaled twice a day for 5 min,. The experimental group was given salbutamol solution twice a day for 5 min, before treatment in the control group, and the children in both groups were treated for 2 weeks. The changes of pulmonary function before and after treatment were compared between the two groups. The levels of EOS,Ig E were observed before and after treatment. Results after treatment, the total effective rate was 98.68% (75 / 76 cases) in the experimental group and 84.13% (53 / 63 cases) in the control group (P0.05). The forced vital capacity (FVC) of the experimental group and the control group were (79.34 卤6.52), () 70.20 卤3.34 L and (80.12 卤3.32), () 68.25 卤2.90 L respectively 3 months after treatment, and (80.12 卤3.32), () of (68.25 卤2.90) L in the first second. Peak expiratory flow rate (PEF) was (82.08 卤9.62), (71.21 卤4.52) L min-1; vital capacity (VC) was (83.42 卤4.10), (73.17 卤2.34) L, the difference was statistically significant (P0.05). The absolute values of peripheral blood EOS were (0.52 卤0.13) 脳 10 ~ 9 / L and (0.96 卤0.23) 脳 10 ~ 9 / L in the experimental group and the control group, respectively. The serum Ig E levels were (105.32 卤62.35), (, 222.58 卤84.71) ng m L -1, P 0.05). Nausea occurred in 1 case (1.59%) in the control group and hoarseness in 2 cases (2.63%) in the experimental group. No adverse drug reactions such as drug allergy, nosocomial infection and rash were found in both groups. There was no significant difference in the incidence of adverse drug reactions between the two groups (P0.05). Conclusion the clinical efficacy of glucocorticoid combined with salbutamol atomization inhalation is significant in children with asthma and can significantly reduce the levels of blood EOS and Ig E and improve pulmonary function.
【作者单位】：郑州市儿童医院东区呼吸科;郑州大学第三附属医院呼吸科;
【基金】：河南省医学科技攻关项目计划基金资助项目(201304023)
【分类号】：R725.6

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