窒息新生儿发生多器官损害的影响因素及临床结局研究

发布时间：2018-12-24 12:12

【摘要】：目的探讨窒息新生儿发生多器官损害的影响因素及临床结局。方法选取2007年10月至2016年4月海南省农垦总医院收治的窒息新生儿115例,依据多器官损害发生情况分为多器官损害组(61例)和无多器官损害组(54例),对入组患儿的临床资料进行单因素和多因素Logistic回归分析,比较两组患儿的临床结局。结果是否存在宫内窘迫、羊水污染、机械通气、不同入院时间、入院pH值、Apgar评分、窒息程度与窒息新生儿的多器官损害发生率有关,差异有统计学意义(P0.05)。宫内窘迫、羊水污染、Apgar评分小于或等于6分、重度窒息是影响窒息新生儿发生多器官损害的独立危险因素(P0.05)。多器官损害组61例,治愈36例(59.02%),死亡14例(22.95%);无多器官损害组54例,治愈50例(92.59%),死亡2例(3.70%),差异有统计学意义(P0.05)。结论窒息新生儿发生多器官损害的风险较高,主要由宫内窘迫、羊水污染、Apgar评分偏低和重度窒息引起,患儿临床结局不佳。
[Abstract]:Objective to investigate the influencing factors and clinical outcome of multiple organ damage in asphyxia neonates. Methods from October 2007 to April 2016, 115 cases of asphyxia neonates admitted in Hainan Agricultural Reclamation General Hospital were divided into multiple organ damage group (61 cases) and no multiple organ damage group (54 cases) according to the occurrence of multiple organ damage. Univariate and multivariate Logistic regression analysis were performed to compare the clinical outcome of the two groups. Results Intrauterine distress, amniotic fluid contamination, mechanical ventilation, different admission time, admission pH value, Apgar score and degree of asphyxia were related to the incidence of multiple organ damage in asphyxia neonates (P0.05). Intrauterine distress amniotic fluid contamination Apgar score less than or equal to 6 severe asphyxia is an independent risk factor affecting multiple organ damage in asphyxia neonates (P0.05). Among 61 cases with multiple organ damage, 36 cases (59.02%) were cured and 14 cases (22.95%) died, while in 54 cases without multiple organ damage, 50 cases (92.59%) were cured and 2 cases (3.70%) died. The difference was statistically significant (P0.05). Conclusion the risk of multiple organ damage in asphyxia neonates is higher, mainly caused by intrauterine distress, amniotic fluid contamination, low Apgar score and severe asphyxia.
【作者单位】：海南省农垦总医院儿科;海南医学院附属医院心内科;
【分类号】：R722.12

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