婴儿期的年龄别体重与幼儿期乙肝疫苗应答的关联

发布时间：2018-12-25 09:02

【摘要】：目的探讨婴儿期的年龄别体重与幼儿期儿童乙肝疫苗应答是否有关联。方法 2013年9月~2015年6月在新疆某三甲医院纳入检测乙肝两对半并完成0~1~6全程接种的儿童,并调查回顾其疫苗接种信息以及0~12月龄身高体重、父母一般情况、母亲孕期、儿童出生情况等。使用年龄别体重及其Z评分(weight for age Z score,WAZ)、年龄别体重偏离情况作为评价体格生长的指标,分析与乙肝疫苗应答的关联。结果 965名儿童纳入研究,男孩490人,女孩475人;平均年龄(1.34±0.56)岁,乙肝抗体阴性儿童占15.23%(147/965),抗体阴性组与阳性组父母一般情况、母亲孕期、儿童出生情况比较,差异均无统计学意义(均有P0.05)。两组儿童1、3、6、9月龄别体重差异均有统计学意义(均有P0.05),阴性组高于阳性组。两组儿童1、3、6年龄WAZ、体重偏离情况差异均有统计学意义(均有P0.05);1月龄(OR=3.409,95%CI:2.199~5.286)、3月龄(OR=5.339,95%CI:3.128~9.113)、6月龄(OR=5.106,95%CI:2.910~8.958)超重者相对正常者的乙肝疫苗不应答率较高;1月龄(OR=3.554,95%CI:2.249~5.616)、3月龄(OR=5.785,95%CI:3.271~10.232)、6月龄(OR=4.486,95%CI:2.642~7.619)体重右偏离者相对正常者的乙肝疫苗不应答率较高。结论接种期(0~6月龄)体重对乙肝疫苗应答有影响,体格生长过快影响乙肝疫苗应答。
[Abstract]:Objective to investigate the relationship between age-specific weight in infancy and hepatitis B vaccine response in young children. Methods from September 2013 to June 2015, children were enrolled in a third Class A Hospital in Xinjiang to detect hepatitis B in two and a half pairs, and to complete the vaccination. The information of vaccination, the height and weight of 0 to 12 months old, the general condition of parents, and the pregnancy of the mother were reviewed. The birth of a child, etc. Age-specific weight and its Z score (weight for age Z score,WAZ) and age-specific weight deviation were used as indicators to evaluate physical growth and the association with hepatitis B vaccine response was analyzed. Results 965 children were included in the study, 490 boys and 475 girls; The average age was (1.34 卤0.56) years old. The proportion of children with negative antibody to hepatitis B was 15.23% (147 / 965). The difference was not statistically significant (P0.05). There was significant difference between the two groups (P0.05), and the negative group was higher than the positive group. There were significant differences in WAZ, body weight deviation between the two groups (P0.05). 1 month old (OR=3.409,95%CI:2.199~5.286), 3 month old (OR=5.339,95%CI:3.128~9.113), 6 month old (OR=5.106,95%CI:2.910~8.958) overweight group had higher hepatitis B vaccine non-response rate than the normal group. 1 month old (OR=3.554,95%CI:2.249~5.616), 3 month old (OR=5.785,95%CI:3.271~10.232), 6 month old (OR=4.486,95%CI:2.642~7.619) right weight deviation group had higher HBV vaccine non-response rate than the normal group. Conclusion body weight during inoculation period (0 ~ 6 months old) has an effect on hepatitis B vaccine response, and rapid physical growth has an effect on hepatitis B vaccine response.
【作者单位】：新疆医科大学公共卫生学院流行病与卫生统计学教研室;
【基金】：新疆维吾尔自治区自然科学基金-医学联合基金(2014211C001) 新疆维吾尔自治区研究生科研创新项目(XJGRI2015079)
【分类号】：R186

【相似文献】