口服锌制剂对轮状病毒感染所致肠炎患儿病情复发的影响

发布时间：2018-12-25 10:07

【摘要】：目的探究口服锌制剂对轮状病毒感染所致肠炎患儿的治疗效果,以及治疗后3、6个月内患儿病情复发情况。方法选取2014年2月-2016年6月于医院接受治疗的162例患儿为研究对象,按照随机数表法平均分成观察组与对照组,每组各81例;对照组接受常规治疗方案,观察组在常规治疗基础上添加口服锌制剂治疗,比较两组患儿治疗效果及治疗前后身体功能性损伤情况,统计并分析两组患儿治疗后肠炎复发例数以及安全性评分。结果观察组患儿接受口服锌制剂治疗后中重度脱水、肝脏功能以及呼吸道损伤症状均有所好转,患儿患病例数明显减少,而对照组患儿治疗后效果不显著,减少的例数不明显;治疗后两组患儿治疗效果差异较大,其中观察组患儿显效率明显高于对照组,两组治疗效果比较,差异有统计学意义(χ~2=6.438,P0.05);病情复发情况显示,观察组及对照组患儿的腹泻呕吐现象随着时间的延长逐渐减少,但对照组患儿在治疗后1、3、6个月三个时间段内腹泻以及呕吐的复发例数均比观察组多,观察组在治疗后6个月的电话随访发现呕吐复发例数仅有2例(2.4%),而腹泻复发例数仅有1例(1.2%),常规治疗添加口服锌制剂治疗轮状病毒较常规治疗有效,治疗后复发率低,差异有统计学意义(χ~2=6.217,P0.05);安全性方面,观察组安全评分(93.13±4.99)分较对照组(75.49±8.41)分高。结论口服锌制剂对轮状病毒感染所致肠炎患儿的治疗效果显著,能有效降低患儿治疗后病情复发率,且能有效减轻病毒感染致肠炎患儿复发时的腹泻、呕吐症状。
[Abstract]:Objective to investigate the therapeutic effect of oral zinc preparation on enteritis caused by rotavirus infection and its recurrence in 3 months and 6 months after treatment. Methods 162 children who were treated in hospital from February 2014 to June 2016 were randomly divided into observation group (n = 81) and control group (n = 81). The patients in the control group were treated with routine treatment regimen, and the patients in the observation group were treated with oral zinc preparation on the basis of routine treatment. The therapeutic effect and functional injury of the body before and after treatment were compared between the two groups. The recurrent cases of enteritis and safety score were analyzed and analyzed in the two groups. Results after treatment with oral zinc preparation, the liver function and respiratory tract injury symptoms were improved, and the number of patients in the observation group was significantly reduced, while the effect of the treatment in the control group was not significant, and the number of cases decreased. There was a significant difference between the two groups after treatment, among which the effective rate of the observation group was significantly higher than that of the control group, and the difference between the two groups was statistically significant (蠂 ~ (2) 6.438 (P0.05). The recurrence of the disease showed that the diarrhea and vomiting in the observation group and the control group gradually decreased with the prolongation of time, but the number of the diarrhea and vomiting in the control group was more than that in the observation group in the period of 3 months, 6 months after treatment, and the incidence of diarrhea and vomiting in the control group was higher than that in the control group. In the observation group, only 2 cases (2.4%) of vomiting recurred and 1 case (1.2%) of diarrhea recurred 6 months after treatment. Routine treatment with oral zinc preparation was more effective than conventional treatment. The recurrence rate was low after treatment, and the difference was statistically significant (蠂 ~ 2 ~ (6.217) P 0.05). The safety score of the observation group (93.13 卤4.99) was higher than that of the control group (75.49 卤8.41). Conclusion the effect of oral zinc preparation on children with enteritis caused by rotavirus infection is remarkable. It can effectively reduce the relapse rate of children with enteritis caused by rotavirus infection, and can effectively reduce the symptoms of diarrhea and vomiting in children with enteritis caused by virus infection.
【作者单位】：儋州市第一人民医院儿科;
【分类号】：R725.1

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